Findings

What do systematic reviews say?

2,087 questions · 2,360 findings · 390 reviews

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No studies found 224 · 9.5%GRADE not reported 603 · 25.6%Very low 555 · 23.5%Low 548 · 23.2%Moderate 312 · 13.2%High 118 · 5%

Resin-modified glass ionomer cement for bonding orthodontic brackets vs Composite resin for bonding brackets

Number of participants with more severe DLs of aesthetic concern · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

Resin-modified glass ionomer cement for bonding orthodontic brackets showed no clear difference in number of participants with more severe DLs of aesthetic concern compared with light-cured composite resin for bonding brackets (low certainty).

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; follow-up 17.6 months
RR 1.18 [0.45, 3.12]
1 study · 173 participants
Low

12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel, professionally applied every 3 months plus home use vs Placebo gel

Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

It is very uncertain whether 12,500 ppm F (NaF/olaflur/dectaflur) amine fluoride gel,… changes number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo gel (very low certainty).

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond; mean follow-up 16.6 months
RR 0.99 [0.76, 1.27]
1 study · 312 participants
Very low

Patient-used 250 ppm F mouthrinse (100 ppm amine F/150 ppm NaF), daily vs 0 ppm F placebo mouthrinse, daily

Number of participants with more severe DLs (severity of DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)

The review found no eligible studies for this question.

1 finding from 1 review

Fluorides for preventing early tooth decay (demineralised lesions) during fixed brace treatment 2019 · Cochrane All outcomes
At debond (end of orthodontic treatment)
SoF 4. Number of participants with more severe DLs: none of the trials reported this outcome.
0 studies
No studies found

Bispectral index vs clinical signs

Occurrence of intraoperative awareness Time points of measure after surgery: 2 to 6 hours;12 hours; 1 day; 2 days; 3 days; 14 days; 30 days; or time point was not reported Measurement tools: simple questioning; interviews; or structured questionna... · adults undergoing surgery with general anaesthesia

Bispectral index may leads to lower occurrence of intraoperative awareness Time points of measure after… compared with clinical signs (low certainty).

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
Peto OR 0.36 [0.21, 0.6]
27 studies · 9765 participants
Low

Bispectral index vs clinical signs

Time to eye opening · adults undergoing surgery with general anaesthesia

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
22 studies · 1494 participants
Low

Bispectral index vs clinical signs

Time to orientation · adults undergoing surgery with general anaesthesia

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
6 studies · 273 participants
Low

Bispectral index vs clinical signs

Time to discharge from the PACU (in minutes) · adults undergoing surgery with general anaesthesia

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 930 participants
Low

Bispectral index vs ETAG

BIS showed no clear difference in occurrence of intraoperative awareness Time points of measure after… compared with ETAG (low certainty).

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
Peto OR 1.13 [0.56, 2.26]
5 studies · 26572 participants
Low

Bispectral index vs ETAG

Time to eye opening · adults undergoing surgery with general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bispectral index vs ETAG

Time to orientation · adults undergoing surgery with general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bispectral index vs ETAG

Time to discharge from the PACU (in minutes) · adults undergoing surgery with general anaesthesia

1 finding from 1 review

Bispectral index for improving intraoperative awareness and early postoperative recovery in adults 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 15452 participants
Low

Intervention not reported

Subgroup 1: Length of hospital stay (days) distal to ligament of Treitz · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
13 studies · 1156 participants
Low

Intervention not reported

Subgroup 2: Length of hospital stay (days) distal and proximal to ligament of Treitz · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 190 participants
Low

Intervention not reported

Subgroup 3: Length of hospital stay (days) oral feeding only · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 1075 participants
Low

Intervention not reported

Subgroup 4: Length of hospital stay (days) tube feeding with/without oral feeding · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 271 participants
Very low

Intervention not reported

Sensitivity analysis 2: Removing studies with imputed results · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 396 participants
Very low

Intervention not reported

Senstivity analysis 3: Worst case scenario imputation · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 235 participants
Low

Intervention not reported

Senstivity analysis 4: Best case scenario imputation · lower gastrointestinal surgery

1 finding from 1 review

Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of… 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 235 participants
Low

Intervention not reported

Overall survival · women with stage Ia2 to IIa cervical cancer

1 finding from 1 review

Nerve‐sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Intervention not reported

Rate of ISC one month after operation · women with stage Ia2 to IIa cervical cancer

1 finding from 1 review

Nerve‐sparing radical hysterectomy compared to standard radical hysterectomy for women with early stage cervical… 2019 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported