Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,320 questions · 4,561 findings · 388 reviews

No studies found 1,138 · 25%GRADE not reported 886 · 19.4%Very low 1,014 · 22.2%Low 849 · 18.6%Moderate 543 · 11.9%High 131 · 2.9%

Patching vs active observation

Motor alignment at near fixation Measured using PACT at 6 months · people with intermittent exotropia, aged less than 11 years

Patching showed no clear difference in motor alignment at near fixation Measured using PACT at 6 months compared with active observation (high certainty).

1 finding from 1 review

Patching vs active observation

Stereoacuity at near · people with intermittent exotropia, aged less than 11 years

Patching showed no clear difference in stereoacuity at near Measured using the Preschool Randot, Titmus… compared with active observation (low certainty).

1 finding from 1 review

Intervention not reported

Episodes of diarrhoea: rate ratios · children up to 15 years of age

The intervention probably leads to lower episodes of diarrhoea: rate ratios (moderate certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Infection or inflammation at individual level (as measured by urinary neopterin, C‐reactive protein or alpha‐1‐acid glycoprotein variant A) · general population of all age groups (including pregnant women) from any country, over two years of age
1 finding from 1 review

iron‐fortified wheat flour with or without other micronutrients added vs fortified wheat flour with same micronutrients (but not iron)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

It is very uncertain whether iron‐fortified wheat flour with or without other micronutrients added changes iron deficiency (as defined by study authors, based on a biomarker… compared with wheat flour (no added iron) with the same other micronutrients added (very low certainty).

1 finding from 1 review

Wheat flour fortified with iron in combination with other micronutrients vs unfortified wheat flour (no micronutrients added)

Iron deficiency (as defined by study authors, based on a biomarker of iron status) · general population of all age groups (including pregnant women) from any country, over two years of age

Iron‐fortified wheat flour with other micronutrients added probably leads to lower iron deficiency (as defined by study authors, based on a biomarker… compared with unfortified wheat flour (no micronutrients added) (moderate certainty).

1 finding from 1 review

Ketamine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 24 hours · adults (aged 18 years+) with depression in bipolar disorder

Ketamine may leads to higher efficacy: number of participants who respond to treatment ‐ at 24… compared with placebo (low certainty).

1 finding from 1 review

Memantine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether memantine changes efficacy: number of participants who respond to treatment ‐ at 1 week compared with placebo (very low certainty).

4 findings from 1 review
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Cytidine vs placebo

Efficacy: number of participants who respond to treatment ‐ at 3 months · adults (aged 18 years+) with depression in bipolar disorder

It is very uncertain whether cytidine changes efficacy: number of participants who respond to treatment ‐ at 3… compared with placebo (very low certainty).

1 finding from 1 review