Cochrane · systematic review · CD004529
Atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria
Blanshard, A, Hine, P · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Infectious DiseasesAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
13
current version
GRADE rated
13
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 10 · 76.9%Moderate 2 · 15.4%High 1 · 7.7%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Atovaquone‐proguanil compared to artemether‐lumefantrine for treating uncomplicated Plasmodium falciparum malaria
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total failure day 28 PCR‐adjusted Atovaquone‐proguanil vs artemether‐lumefantrine | RR 5 [0.25, 99.95] | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Total failure day 42 PCR‐unadjusted Atovaquone‐proguanil vs artemether‐lumefantrine | RR 5 [0.25, 99.95] | 1 study · 60 participants | Low Downgraded: imprecision, indirectness |
Total failure day 42 PCR‐adjusted Atovaquone‐proguanil vs artemether‐lumefantrine | RR 3 [0.19, 47.12] | 1 study · 208 participants | Low Downgraded: imprecision, indirectness |
Atovaquone‐proguanil compared to artesunate‐amodiaquine for treating uncomplicated Plasmodium falciparum malaria
Population: children under the age of 5 years
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total failure day 28 PCR‐adjusted Atovaquone‐proguanil vs artesunate‐amodiaquine | RR 3.19 [0.67, 15.22] | 1 study · 132 participants | Low Downgraded: imprecision, indirectness |
Total failure day 28 PCR‐unadjusted Atovaquone‐proguanil vs artesunate‐amodiaquine | RR 1.2 [0.49, 2.91] | 1 study · 132 participants | Low Downgraded: imprecision, indirectness |
Early treatment failure Atovaquone‐proguanil vs artesunate‐amodiaquine | RR 13.8 [0.79, 240.11] | 1 study · 132 participants | Low Downgraded: imprecision, indirectness |
Atovaquone‐proguanil compared to artesunate‐mefloquine for treating uncomplicated Plasmodium falciparum malaria
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total failure day 42 PCR‐adjusted Atovaquone‐proguanil vs artesunate‐mefloquine | RR 1.15 [0.57, 2.34] | 2 studies · 1168 participants | High |
Total failure day 42 PCR‐unadjusted Atovaquone‐proguanil vs artesunate‐mefloquine | RR 0.8 [0.5, 1.3] | 1 study · 1063 participants | Low Downgraded: imprecision |
Atovaquone‐proguanil compared to artesunate‐atovaquone‐proguanil for treating uncomplicated Plasmodium falciparum malaria
Population: children and adults
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Total failure day 28 PCR‐adjusted Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil | RR 5.143 [0.61, 43.52] | 2 studies · 375 participants | Low Downgraded: imprecision |
Total failure day 28 PCR‐unadjusted Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil | RR 15.48 [0.9, 267.27] | 1 study · 187 participants | Low Downgraded: imprecision, indirectness |
Total failure [day 42 PCR‐adjusted Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil | RR 1.84 [0.95, 3.56] | 2 studies · 1258 participants | Moderate Downgraded: imprecision |
Total failure day 42 PCR‐unadjusted Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil | RR 1.56 [0.88, 2.79] | 1 study · 1063 participants | Moderate Downgraded: imprecision |
Early treatment failure Atovaquone‐proguanil vs artesunate‐atovaquone‐proguanil | RR 5.11 [0.25, 104.94] | 2 studies · 395 participants | Low Downgraded: imprecision |