Findings

What do systematic reviews say?

2,261 questions · 2,280 findings · 114 reviews · Cystic Fibrosis and Genetic Disorders

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No studies found 856 · 37.5%GRADE not reported 58 · 2.5%Very low 550 · 24.1%Low 502 · 22%Moderate 271 · 11.9%High 43 · 1.9%

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Prevention of adrenal crisis · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Presence of osteopenia · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Presence of testicular or ovarian adrenal rest tumours · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Subfertility · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (13.5 mg/m²/day to 15.5 mg/m²/day): high morning dose vs high evening dose

Final adult height · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

QoL · people with CAH

The review found no eligible studies for this question.

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HC (15 mg/m²/day) vs PD (3 mg/m²/day) versus DXA (0.3 mg/m²/day)

Androgen normalisation · people with CAH

1 finding from 1 review

Glucocorticoid replacement regimens for treating congenital adrenal hyperplasia 2020 · Cochrane Headline outcomes only
no estimate extracted
9 participants
Very low

Intervention not reported

Pain relief (percentage relief compared to baseline) · children and young adults with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Pain intensity (visual analogue score from 0 to 10 where 10 is the most severe pain) · children and young adults with SCD

It is very uncertain whether the intervention changes pain intensity (visual analogue score from 0 to 10 where 10 is the… (very low certainty).

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Intervention not reported

Frequency of pain episodes · children and young adults with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Change in consumption of analgesics (number of participants requiring analgesia) · children and young adults with SCD

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Intervention not reported

Change in QoL · children and young adults with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Change in ability to cope with ADL · children and young adults with SCD

The review found no eligible studies for this question.

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Intervention not reported

Adverse effects · children and young adults with SCD

1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) for pain management in sickle cell disease 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 22 participants
Very low

Probiotics vs placebo

Pulmonary exacerbations · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 225 participants
Low

Probiotics vs placebo

Faecal calprotectin · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 177 participants
Low

Probiotics vs placebo

Adverse events (serious adverse reaction and adverse reaction) · children and adults with CF

Probiotics showed no clear difference in adverse events (serious adverse reaction and adverse reaction) compared with placebo (low certainty).

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
RR 3 [0.49, 18.46]
5 studies · 310 participants
Low

Probiotics vs placebo

Weight (z score) · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 91 participants
Low

Probiotics vs placebo

FEV1 % predicted · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 284 participants
Low

Probiotics vs placebo

Hospitalisation (any cause) · children and adults with CF

1 finding from 1 review

Probiotics for people with cystic fibrosis 2020 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 115 participants
Low