Findings

What do systematic reviews say?

2,532 questions · 2,642 findings · 483 reviews · Headline outcomes only

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No studies found 534 · 20.2%GRADE not reported 82 · 3.1%Very low 641 · 24.3%Low 807 · 30.5%Moderate 472 · 17.9%High 106 · 4%

SSRIs or SNRIs vs other antidepressants

Withdrawals due to adverse events · patients with tension‐type headache

SSRIs or SNRIs showed no clear difference in withdrawals due to adverse events compared with other antidepressants (low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 1.04 [0.41, 2.6]
4 studies · 257 participants
Low

SSRIs or SNRIs vs placebo

Headache duration (hours) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Low

SSRIs or SNRIs vs placebo

Symptomatic/analgesic medication use for acute headache attacks · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 118 participants
Low

SSRIs or SNRIs vs placebo

Headache index · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 128 participants
Very low

SSRIs or SNRIs vs placebo

Quality of life · patients with tension‐type headache

The review found no eligible studies for this question.

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

SSRIs or SNRIs vs placebo

Withdrawals due to adverse events · patients with tension‐type headache

It is very uncertain whether SSRIs or SNRIs changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
OR 3.72 [0.79, 17.53]
3 studies · 190 participants
Very low

SSRIs or SNRIs vs other antidepressants

Headache (frequency) · patients with tension‐type headache

1 finding from 1 review

Selective serotonin reuptake inhibitors (SSRIs) and serotonin‐norepinephrine reuptake inhibitors (SNRIs) for the… 2015 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 152 participants
Very low

Intervention not reported

Systolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 663 participants
Moderate

Intervention not reported

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
8 studies · 662 participants
Moderate

Intervention not reported

Systolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
47 studies · 7733 participants
High

Intervention not reported

Diastolic blood pressure · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
51 studies · 8064 participants
High

Intervention not reported

Withdrawal due to adverse effects · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 3698 participants
Very low

Inhaled NO vs placebo or conventional therapy

Long‐term mortality · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
0 studies · 0 participants
GRADE not reported

Inhaled NO vs placebo or conventional therapy

Mortality before hospital discharge · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

It is very uncertain whether inhaled nitric oxide changes mortality prior to discharge1 compared with placebo or conventional therapy (very low certainty).

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
OR 1.67 [0.38, 7.3]
2 studies · 162 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Conventional Management4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MPAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Conventional Mangement4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 4 participants
Very low

Inhaled NO vs placebo or conventional therapy

Difference in MAP change score (SE) ‐ Placebo4 · all infants and children with congenital heart disease having postoperative management of pulmonary hypertension

1 finding from 1 review

Inhaled nitric oxide for the postoperative management of pulmonary hypertension in infants and children with… 2014 · Cochrane Headline outcomes only
no estimate extracted
1 study · 2 participants
Very low

Intervention not reported

Decrease in systolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low

Intervention not reported

Decrease in diastolic blood pressure · Adults with primary hypertension

1 finding from 1 review

Blood pressure lowering efficacy of partial agonist beta blocker monotherapy for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 490 participants
Very low