Cochrane · systematic review · CD003824
Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension
Musini, VM, Nazer, M, Bassett, K, et al. · Cochrane Database of Systematic Reviews · 2014 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
5
current version
GRADE rated
5
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 1 · 20%Low 0 · 0%Moderate 2 · 40%High 2 · 40%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Dose‐ranging blood pressure‐lowering efficacy of hydrochlorothiazide for primary hypertension
Population: adults with primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic blood pressure | no estimate extracted | 8 studies · 663 participants | Moderate Downgraded: imprecision |
Diastolic blood pressure | no estimate extracted | 8 studies · 662 participants | Moderate Downgraded: imprecision |
Overall effects of thiazides for primary hypertension
Population: adults with primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic blood pressure | no estimate extracted | 47 studies · 7733 participants | High |
Diastolic blood pressure | no estimate extracted | 51 studies · 8064 participants | High |
Withdrawal due to adverse effects | no estimate extracted | 20 studies · 3698 participants | Very low Downgraded: risk of bias |