Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

186 questions · 191 findings · 36 reviews · Headline outcomes only

No studies found 19 · 9.9%GRADE not reported 13 · 6.8%Very low 68 · 35.6%Low 55 · 28.8%Moderate 26 · 13.6%High 10 · 5.2%

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Iron deficiency (using ferritin concentrations) · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) probably leads to lower iron deficiency (defined by using ferritin concentrations less than… compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Diarrhoea · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in diarrhoea (≥ 3 liquid stools per day) compared with no intervention or placebo (low certainty).

1 finding from 1 review

Home (point‐of‐use) fortification of foods with multiple micronutrient powders vs placebo or no intervention

Any adverse effects (e.g. hypervitaminosis A, as defined by the trialists) · preschool and school‐age children

Point‐of‐use fortification of foods with micronutrients powders (MNP) showed no clear difference in adverse effects (any, as defined by trialists) compared with no intervention or placebo (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of subjects who had one or more exacerbations over the study period in adults ( · Adults and children with asthma

The intervention showed no clear difference in number of subjects who had one or more exacerbations over the study… (moderate certainty).

1 finding from 1 review

Intervention not reported

In‐hospital mortality · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…

The intervention showed no clear difference in in‐hospital mortality (low certainty).

1 finding from 1 review

Intervention not reported

Rate of barotrauma · mechanically ventilated adults with acute respiratory distress syndrome. Participants were recruited from ICUs internationally, including…

The intervention showed no clear difference in rate of barotrauma (moderate certainty).

1 finding from 1 review

Intervention not reported

Change in pain Visual Analog Scale (VAS) at 12 weeks (0 to 10 scale; lower score means less pain) · people with rheumatoid arthritis

It is very uncertain whether the intervention changes change in pain Visual Analog Scale (VAS) at 12 weeks (0 to 10 scale;… (very low certainty).

1 finding from 1 review