Cochrane · systematic review · CD012649
Provision of folic acid for reducing arsenic toxicity in arsenic‐exposed children and adults
Bae, S, Kamynina, E, Guetterman, HM, et al. · Cochrane Database of Systematic Reviews · 2021 · Cochrane Library
Developmental, Psychosocial and Learning ProblemsAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
14
current version
GRADE rated
6
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 8 · 57.1%Very low 0 · 0%Low 3 · 21.4%Moderate 3 · 21.4%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Folic acid supplements alone versus placebo for reducing arsenic toxicity in arsenic‐exposed adults
Population: adult men and women who had been exposed to arsenic‐containing drinking water
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any type of cancer Folic acid supplements alone vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
All‐cause mortality Folic acid supplements alone vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurocognitive function Folic acid supplements alone vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Any congenital anomalies Folic acid supplements alone vs placebo | no estimate extracted | 0 studies · 0 participants | Ungraded |
Blood arsenic Measured by change in total blood arsenic, InAs, MMA, and DMA from baseline to week 12 Folic acid supplements alone vs placebo | no estimate extracted | 2 studies · 536 participants | Moderate Downgraded: imprecision |
Urinary arsenic Measured by change in percentage (%) of InAs, MMA, and DMA from baseline to week 12 Folic acid supplements alone vs placebo | no estimate extracted | 2 studies · 546 participants | Moderate Downgraded: imprecision |
Plasma homocysteine Measured by change in plasma homocysteine concentrations from baseline to week 12 Folic acid supplements alone vs placebo | no estimate extracted | 2 studies · 448 participants | Moderate Downgraded: imprecision |
Folic acid supplements plus other nutrient supplements versus nutrient supplements alone for reducing arsenic toxicity in arsenic‐exposed adults
Population: adult men and women who had been drinking from a household well with water arsenic concentrations greater than 50 μg/L for at least 1 year
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Any type of cancer Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 0 studies · 0 participants | Ungraded |
All‐cause mortality Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 0 studies · 0 participants | Ungraded |
Neurocognitive function Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 0 studies · 0 participants | Ungraded |
Any congenital anomalies Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 0 studies · 0 participants | Ungraded |
Blood arsenic Measured by change in GM of blood arsenic concentrations from baseline to week 12 Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 1 study · 204 participants | Low Downgraded: imprecision |
Urinary arsenic Measured by percentage (%) of InAs, MMA, and DMA from baseline to week 12 Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 1 study · 190 participants | Low Downgraded: imprecision |
Plasma homocysteine Measured by change in GM of plasma homocysteine concentrations from baseline to week 12 Folic acid supplements plus other nutrient supplements vs nutrient supplements alone | no estimate extracted | 1 study · 204 participants | Low Downgraded: imprecision |