Findings

What do systematic reviews say?

204 questions · 206 findings · 24 reviews · Headline outcomes only

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No studies found 98 · 47.6%GRADE not reported 4 · 1.9%Very low 54 · 26.2%Low 43 · 20.9%Moderate 6 · 2.9%High 1 · 0.5%

Isoxsuprine vs placebo

Change in ulcer size · individuals with sickle cell disease and a leg ulcer

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 40 participants
Very low

Solcoseryl vs antiseptic agent

Change in ulcer size · individuals with sickle cell disease and a leg ulcer

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Duoderm® (hydroactive dressing) vs antiseptic agent

Change in ulcer size · individuals with sickle cell disease and a leg ulcer

1 finding from 1 review

Interventions for treating leg ulcers in people with sickle cell disease 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 35 participants
Very low

Aqueous oxygen peroxide vs placebo (saline solution or sterile water)

Change in ulcer size · people with venous leg ulcers

1 finding from 1 review

Wound cleansing for treating venous leg ulcers 2021 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Very low

Topical antimicrobial agent vs alternative antimicrobial agent

Change in wound surface area over time or partial healing (> 95%) (12 months) · people with facial burns

1 finding from 1 review

Topical treatment for facial burns 2020 · Cochrane Headline outcomes only
no estimate extracted
142 participants
Low

Skin substitute vs topical antimicrobial agent

Change in wound surface area over time or partial wound healing (> 90%) (until wound healing) · people with facial burns

1 finding from 1 review

Topical treatment for facial burns 2020 · Cochrane Headline outcomes only
no estimate extracted
34 participants
Low

Miscellaneous treatment vs miscellaneous treatments

Change in wound surface area over time or partial healing (> 95%) (12 months) · people with facial burns

1 finding from 1 review

Topical treatment for facial burns 2020 · Cochrane Headline outcomes only
no estimate extracted
2011 participants
GRADE not reported

Topical antimicrobial agent vs topical non‐antimicrobial agent

Change in wound surface area over time or partial healing – not measured

The review found no eligible studies for this question.

1 finding from 1 review

Topical treatment for facial burns 2020 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Topical cyclosporine A 0.05% + artificial tears vs vehicle + artificial tears or artificial tears alone

Ocular surface staining · people with dry eye

1 finding from 1 review

Topical cyclosporine A therapy for dry eye syndrome 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 291 participants
Low

Oral omega‐3 PUFAs plus conventional therapy vs conventional therapy

Ocular surface staining · people with dry eyea

The review found no eligible studies for this question.

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral long‐chain omega‐3 PUFAs vs placebo or no treatment

Change in ocular surface staining at 1‐month (with actual · people with dry eyea

Oral long‐chain omega‐3 PUFAs (ie, EPA and DHA) showed no clear difference in change in ocular surface staining at 1‐month (with actual compared with placebo or no treatment (low certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
MD 0.1
4 studies · 681 participants
Low

Oral long‐chain omega‐3 PUFAs vs oral omega‐6 PUFAs

Ocular surface staining · people with dry eyea

Oral long‐chain omega‐3 PUFAs showed no clear difference in change in ocular surface staining at 1‐month compared with oral omega‐6 PUFAs (low certainty).

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 709 participants
Low

Combined oral omega‐3 and omega‐6 PUFAs vs placebo

Ocular surface staining · people with dry eyea

1 finding from 1 review

Omega‐3 and omega‐6 polyunsaturated fatty acids for dry eye disease 2019 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 3 participants
Moderate

Fexofenadine 120 mg/d vs placebo (1‐week intervention)

Secondary outcome 1. Mean change in physician‐assessed clinical signs This outcome was assessed as investigator‐assessed change in the ratio of pruritus area to body surface area · adults with eczema

1 finding from 1 review

Oral H1 antihistamines as ‘add‐on’ therapy to topical treatment for eczema 2019 · Cochrane Headline outcomes only
no estimate extracted
1 study · 1 participants
Moderate

Enhanced multidisciplinary team (EMDT) vs usual care

Reduction in pressure ulcer surface area · people with pressure ulcers residing in long‐term‐care facilities

1 finding from 1 review

Organisation of health services for preventing and treating pressure ulcers 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 161 participants
Very low

Summary of findings: punctal plugs vs pilocarpine

Ocular surface staining · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Summary of findings: punctal plugs vs no punctal plugs

Ocular surface staining · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 61 participants
Low

Summary of findings: punctal plugs vs artificial tears

Ocular surface staining · adults with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Summary of findings: punctal plugs in the upper vs lower puncta

Ocular surface staining · adults with dry eye syndrome

The review found no eligible studies for this question.

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Summary of findings: acrylic vs silicone punctal plugs

Ocular surface staining · mostly women with dry eye syndrome

1 finding from 1 review

Punctal occlusion for dry eye syndrome 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low