Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

286 questions · 318 findings · 37 reviews · Developmental, Psychosocial and Learning Problems

No studies found 53 · 16.7%GRADE not reported 19 · 6%Very low 84 · 26.4%Low 96 · 30.2%Moderate 60 · 18.9%High 6 · 1.9%

BoNT‐A vs sham

Observational gait analysis (improvement) · children with CP

BoNT‐A probably leads to higher observational gait analysis (improvement) compared with placebo or sham (moderate certainty).

2 findings from 1 review

BoNT‐A vs sham

Function · children with CP
3 findings from 1 review

BoNT‐A vs sham

Range of motion (passive ankle dorsiflexion) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Satisfaction · children with CP
3 findings from 1 review

BoNT‐A vs sham

Spasticity (ankle plantarflexors) · children with CP
3 findings from 1 review

BoNT‐A vs sham

Adverse events · children with CP

BoNT‐A showed no clear difference in adverse events compared with placebo or sham (moderate certainty).

3 findings from 1 review

BoNT‐A vs sham

Instrumented gait analysis (kinematics) (not measured) · children with CP

The review found no eligible studies for this question.

2 findings from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… may leads to lower anaemia (haemoglobin concentration below a cut‐off defined by the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency (as defined by trialists) · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency (as defined by trialists by using indicators of iron… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Iron deficiency anaemia · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in iron deficiency anaemia (as defined by the presence of anaemia plus… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

All‐cause morbidity · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in all‐cause morbidity (the most frequent event associated with the… compared with no supplementation or placebo (low certainty).

1 finding from 1 review

Intermittent iron supplementation (alone or with any other micronutrients) vs no supplementation or placebo

Side effects or other adverse events · adolescent and adult menstruating women

Intermittent iron supplementation (alone or with any other… showed no clear difference in any adverse side effects compared with no supplementation or placebo (moderate certainty).

1 finding from 1 review

Prophylactic probiotics vs placebo

Occurrence of new cases of colic Measured by: Wessel/Rome III Criteria · infants without colic

Prophylactic probiotics showed no clear difference in occurrence of new cases of colic Measured by: Wessel/Rome III Criteria compared with placebo (low certainty).

1 finding from 1 review

Prophylactic probiotics vs placebo

Adverse effects Measured by: reporting · infants without colic

Prophylactic probiotics showed no clear difference in adverse effects Measured by: reporting compared with placebo (low certainty).

1 finding from 1 review