What do systematic reviews say?

Valproate vs placebo

It is very uncertain whether valproate preparations changes serious adverse events by 6 weeks compared with placebo (very low certainty).

• Valproate preparations for agitation in dementia 2018 · Cochrane Headline outcomes only
  OR 4.77 [1, 22.74]
  2 studies · 228 participants
  Very low

Antipsychotics vs nonantipsychotics or placebo

The review found no eligible studies for this question.

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antipsychotics vs nonantipsychotics or placebo

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 494 participants
  Very low

Antipsychotics vs nonantipsychotics or placebo

It is very uncertain whether antipsychotics changes delirium resolution DRS, DRS‐R981 compared with nonantipsychotics or placebo (very low certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 0.95 [0.3, 2.98]
  3 studies · 247 participants
  Very low

Antipsychotics vs nonantipsychotics or placebo

Antipsychotics showed no clear difference in mortality compared with nonantipsychotics or placebo (moderate certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 1.29 [0.73, 2.27]
  3 studies · 319 participants
  Moderate

Antipsychotics vs nonantipsychotics or placebo

The review found no eligible studies for this question.

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Antipsychotics vs nonantipsychotics or placebo

It is very uncertain whether antipsychotics changes adverse Effects ‐ EPS Extrapyramidal Symptom Rating Scale, or not… compared with nonantipsychotics or placebo (very low certainty).

• Antipsychotics for treatment of delirium in hospitalised non‐ICU patients 2018 · Cochrane Headline outcomes only
  RR 1.7 [0.04, 65.57]
  3 studies · 247 participants
  Very low

B vitamins vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E vs placebo

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  Low

Vitamin E vs placebo

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  Low

Vitamin E vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E vs placebo

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1 participants
  GRADE not reported

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E + vitamin C vs placebo

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 256 participants
  Very low

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

B vitamins vs placebo

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 488 participants
  Very low

Vitamin E + vitamin C vs placebo

The review found no eligible studies for this question.

• Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild… 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found