Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

328 questions · 332 findings · 35 reviews

No studies found 83 · 25%GRADE not reported 11 · 3.3%Very low 75 · 22.6%Low 105 · 31.6%Moderate 45 · 13.6%High 13 · 3.9%

NSAIDs vs placebo or no treatment

AKI within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes AKI within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

RRT within 30 days of surgery · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes RRT within 30 days of surgery compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

Death (all causes) · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes death (all causes) compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs vs placebo or no treatment

Length of hospital stay · adults with normal kidney function undergoing surgery

It is very uncertain whether nonsteroidal anti‐inflammatory drugs (NSAIDs) changes length of hospital stay compared with placebo or no treatment (very low certainty).

1 finding from 1 review

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3, Clinical resolution (not completely resolved) at 3 months: '1 study evaluated systemic treatment and 1 evaluated topical treatment. Neither found benefit for NSAIDs.' No GRADE. Effects text: celecoxib…
    2 studies
    GRADE not reported

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Safety of the intervention (adverse effects) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3, Safety of the intervention over 3 months: systemic celecoxib (1 study) - 32 intervention participants reported 56 adverse effects, 20 placebo participants reported 20; 4 grade 3 events; 2 discontinued. Ketorolac…
    2 studies
    GRADE not reported

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Improvement of histological features (not improved) · People with a diagnosis of oral leukoplakia

The review found no eligible studies for this question.

1 finding from 1 review

NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment

Malignant transformation (oral cancer development) · People with a diagnosis of oral leukoplakia
1 finding from 1 review
  • SoF 3 (NSAIDs vs placebo), Cancer development: SoF cell 'Not measured'. Effects text: cancer development was among outcomes in Papadimitrakopoulou 2008 (celecoxib) but did not occur in either arm, probably because of…
    1 study
    GRADE not reported

Summary of findings for NSAIDs plus corticosteroids vs corticosteroids

Proportion of participants with cystoid macular edema 1 week · people who received phacoemulsification

Summary of findings for NSAIDs plus corticosteroids may leads to lower proportion of participants with cystoid macular edema 1 week compared with corticosteroids alone (low certainty).

1 finding from 1 review