Question · asked by 1 review
NSAIDs (ketorolac oral rinse; systemic celecoxib) vs placebo or no treatment: Clinical resolution (oral lesion not completely resolved)
- Population
- People with a diagnosis of oral leukoplakia
- Intervention
- NSAIDs (ketorolac oral rinse; systemic celecoxib)
- Comparison
- placebo or no treatment
- Outcome
- Clinical resolution (oral lesion not completely resolved)
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
NSAIDs (ketorolac oral rinse; systemic celecoxib) vs Placebo or no treatment Clinical resolution (oral lesion not completely resolved) · People with a diagnosis of oral leukoplakia · 3 months Interventions for treating oral leukoplakia to prevent oral cancer (2016) · Cochrane All outcomes | SoF 3, Clinical resolution (not completely resolved) at 3 months: '1 study evaluated systemic treatment and 1 evaluated topical treatment. Neither found benefit for NSAIDs.' No GRADE. Effects text: celecoxib… | 2 studies | GRADE not reported |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Interventions for treating oral leukoplakia to prevent oral cancer 2016 · Cochrane All outcomes | 2016-05 | Not listed | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.