Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 205 findings · 42 reviews

No studies found 23 · 11.2%GRADE not reported 64 · 31.2%Very low 31 · 15.1%Low 51 · 24.9%Moderate 33 · 16.1%High 3 · 1.5%

Self‐monitoring or self‐management of oral anticoagulation vs usual care

All‐cause mortality · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring or self‐management of oral anticoagulation showed no clear difference in all‐cause mortality compared with standard care (moderate certainty).

1 finding from 1 review

Self‐monitoring or self‐management of oral anticoagulation vs usual care

Major bleeding · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring or self‐management of oral anticoagulation showed no clear difference in major haemorrhage compared with standard care (moderate certainty).

1 finding from 1 review

Self‐monitoring or self‐management of oral anticoagulation vs usual care

Minor haemorrhage · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring or self‐management of oral anticoagulation showed no clear difference in minor haemorrhage compared with standard care (low certainty).

1 finding from 1 review

Self‐monitoring of oral anticoagulation vs usual care

Thromboembolic events · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring of oral anticoagulation probably leads to lower thromboembolic events compared with standard care (moderate certainty).

1 finding from 1 review

Self‐monitoring of oral anticoagulation vs usual care

All‐cause mortality · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring of oral anticoagulation showed no clear difference in all‐cause mortality compared with standard care (moderate certainty).

1 finding from 1 review

Self‐monitoring of oral anticoagulation vs usual care

Major bleeding · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring of oral anticoagulation showed no clear difference in major haemorrhage compared with standard care (low certainty).

1 finding from 1 review

Self‐monitoring of oral anticoagulation vs usual care

Minor haemorrhage · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

Self‐monitoring of oral anticoagulation showed no clear difference in minor haemorrhage compared with standard care (moderate certainty).

1 finding from 1 review

self‐management of oral anticoagulation vs usual care

Thromboembolic events · Patients on long‐term anticoagulant therapy (treatment duration longer than two months) irrespective of the indication for treatment

self‐management of oral anticoagulation probably leads to lower thromboembolic events compared with standard care (moderate certainty).

1 finding from 1 review

Intervention not reported

Clinical failure—primary outcome (by intention‐to‐treat analysis) · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention probably leads to lower clinical failure—primary outcome (by intention‐to‐treat analysis) (moderate certainty).

1 finding from 1 review

Intervention not reported

PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each question has a 7‐point score ranging from 1 (worst quality of life) to 7 (best quality of life). Scores for each item were added and the average taken · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention probably leads to higher PC‐QOL mean score at 6 weeks PC‐QOL is a 27‐item questionnaire. Each… (moderate certainty).

1 finding from 1 review

Intervention not reported

Duration of cough post randomisation · children with chronic cough of unknown origin lasting longer than 4 weeks

The intervention showed no clear difference in duration of cough post randomisation (moderate certainty).

1 finding from 1 review

Intervention not reported

Proportion of adverse events experienced · children with chronic cough of unknown origin lasting longer than 4 weeks
1 finding from 1 review

Intervention not reported

Proportions of participants experiencing adverse events or complications · children with chronic cough of unknown origin lasting longer than 4 weeks
1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: in‐hospital mortality (time points varied) · all conditions

Transfusion of RBCs of shorter showed no clear difference in mortality: in‐hospital mortality (time points varied) compared with standard practice storage duration (moderate certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ neonates · all conditions

It is very uncertain whether transfusion of RBCs of shorter changes mortality: short‐term mortality (up to 30 days) ‐ neonates compared with standard practice storage duration (very low certainty).

1 finding from 1 review

Transfusion of RBCs of shorter vs standard practice storage duration

Mortality: short‐term mortality (up to 30 days) ‐ adults · all conditions

Transfusion of RBCs of shorter showed no clear difference in mortality: short‐term mortality (up to 30 days) ‐ adults compared with standard practice storage duration (moderate certainty).

1 finding from 1 review