Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

294 questions · 295 findings · 16 reviews · Schizophrenia

No studies found 79 · 26.8%GRADE not reported 32 · 10.8%Very low 99 · 33.6%Low 55 · 18.6%Moderate 17 · 5.8%High 13 · 4.4%

HALOPERIDOL vs first‐generation antipsychotics

Adverse events as N of participants with at least one adverse event objective · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: number of participants with at least one adverse… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Adverse effects: extrapyramidal side effects: number of participants with at least one extrapyramidal side effect (medium term) · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: extrapyramidal side effects: number of participants… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Behaviour: Leaving the study early (short‐term) · patients with schizophrenia

Haloperidol showed no clear difference in leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ short term ‐ due to lack of efficacy · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to inefficacy of treatment as a measure… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ due to adverse effects (short term) · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to adverse events as a measure of… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Number of participants reporting an adverse event · patients with schizophrenia

Haloperidol showed no clear difference in adverse effects: number of participants with at least one adverse… compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether haloperidol changes adverse effects: extrapyramidal side effects: number of participants… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Response to treatment (medium term) Clinically important response to treatment as defined by each study · patients with schizophrenia

Haloperidol may leads to lower clinically important response to treatment (medium term) compared with first‐generation antipsychotics (low certainty).

1 finding from 1 review

HALOPERIDOL vs first‐generation antipsychotics

Leaving the study early ‐ medium term ‐ any reason · patients with schizophrenia

It is very uncertain whether haloperidol changes leaving the study early due to any reason as a measure of overall… compared with first‐generation antipsychotics (very low certainty).

1 finding from 1 review

HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Risk for at least one adverse event per patient · patients with schizophrenia

It is very uncertain whether HALOPERIDOL changes adverse effects ‐ at least one adverse effect compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (very low certainty).

1 finding from 1 review

HALOPERIDOL vs LOW‐POTENCY ANTIPSYCHOTIC DRUGS

Adverse effects ‐ movement disorders ‐ At least one movement disorder · patients with schizophrenia

HALOPERIDOL may leads to higher adverse effects ‐ movement disorders ‐ At least one movement disorder compared with LOW‐POTENCY ANTIPSYCHOTIC DRUGS (low certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Global state: no overall improvement (psychiatrist ‐ rated) · patients with schizophrenia

HALOPERIDOL probably leads to lower overall improvement: No marked global improvement Rated by clinician compared with PLACEBO (moderate certainty).

1 finding from 1 review

HALOPERIDOL vs placebo

Not discharged from hospital · patients with schizophrenia

It is very uncertain whether HALOPERIDOL changes not discharged from hospital compared with PLACEBO (very low certainty).

1 finding from 1 review