All‐cause mortality at 28 days and before discharge from hospital · preterm born neonates
1 finding from 1 review
Nitrogen balance · preterm born neonates
1 finding from 1 review
Intervention not reported
Necrotising enterocolitis prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants
The intervention may leads to lower necrotising enterocolitis prior to hospital discharge (low certainty).
1 finding from 1 review
Intervention not reported
Mortality prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants
The intervention showed no clear difference in mortality prior to hospital discharge (low certainty).
1 finding from 1 review
Intervention not reported
Feed intolerance prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants
The intervention may leads to lower feed intolerance prior to hospital discharge (low certainty).
1 finding from 1 review
Intervention not reported
Invasive infection prior to hospital discharge · very preterm (< 32 weeks' gestation) or very low birth weight (< 1500 g) infants
The intervention probably leads to higher invasive infection prior to hospital discharge (moderate certainty).
1 finding from 1 review
Weight gain · preterm or low birth weight infants
1 finding from 1 review
Necrotising enterocolitis · preterm or low birth weight infants
It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).
1 finding from 1 review
Linear growth during hospital stay (cm/week) · preterm or low birth weight infants
1 finding from 1 review
Growth: head circumference (cm/week) · preterm or low birth weight infants
1 finding from 1 review
Extrauterine growth restriction at discharge · preterm or low birth weight infants
High showed no clear difference in extrauterine growth restriction at discharge compared with standard volume of fortified human milk or preterm formula (low certainty).
1 finding from 1 review
Necrotising enterocolitis · preterm or low birth weight infants
It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of fortified human milk or preterm formula (very low certainty).
1 finding from 1 review
Weight gain · preterm or low birth weight infants
1 finding from 1 review
Linear growth (cm/week) · preterm or low birth weight infants
1 finding from 1 review
Growth: head circumference (cm/week) · preterm or low birth weight infants
1 finding from 1 review
Extrauterine growth restriction at discharge · preterm or low birth weight infants
1 finding from 1 review
All‐cause Mortality№ of participants: 5510(11 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants
It is very uncertain whether lactoferrin supplementation changes all‐cause Mortality№ of participants: 5510(11 RCTs) compared with control (very low certainty).
1 finding from 1 review
RR 0.97 [0.79, 1.2]
Studies not reported
Very low
necrotizing enterocolitis№ of participants: 4874(7 RCTs) · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in necrotizing enterocolitis№ of participants: 4874(7 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.9 [0.69, 1.17]
Studies not reported
Low
Any late‐onset sepsis ‐ all infants · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation may leads to lower late onset sepsis№ of participants: 5425(12 RCTs) [Data includes… compared with control (low certainty).
1 finding from 1 review
RR 0.8 [0.72, 0.89]
Studies not reported
Low
Bacterial sepsis · prevention of sepsis and necrotizing enterocolitis in preterm infants
Lactoferrin supplementation showed no clear difference in bacterial sepsis№ of participants: 3565(8 RCTs) compared with control (low certainty).
1 finding from 1 review
RR 0.86 [0.74, 1]
Studies not reported
Low