Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

332 questions · 335 findings · 55 reviews · Headline outcomes only

No studies found 77 · 23%GRADE not reported 3 · 0.9%Very low 113 · 33.7%Low 75 · 22.4%Moderate 61 · 18.2%High 6 · 1.8%

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Endoscopic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes endoscopic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic response · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: video‐assisted vs. endoscopic · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: video‐assisted vs. endoscopic (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: video‐assisted vs. endoscopic · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: video‐assisted vs. endoscopic (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: video‐assisted vs. endoscopic · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: video‐assisted vs. endoscopic (very low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic drainage versus EUS‐guided drainage · patients with pancreatic pseudocysts

It is very uncertain whether the intervention changes endoscopic drainage versus EUS‐guided drainage (very low certainty).

1 finding from 1 review