Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

334 questions · 337 findings · 56 reviews

No studies found 77 · 22.8%GRADE not reported 5 · 1.5%Very low 113 · 33.5%Low 75 · 22.3%Moderate 61 · 18.1%High 6 · 1.8%

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Endoscopic relapse · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes endoscopic relapse compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Intervention not reported

Endoscopic response · Patients with active Crohn's disease

The review found no eligible studies for this question.

1 finding from 1 review

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash vs Sucralfate mouthwash

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults receiving radiotherapy to the head and neck

Granulocyte-macrophage colony-stimulating factor (GM-CSF), mouthwash showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with sucralfate mouthwash; GRADE not reported.

1 finding from 1 review

On‐demand deprescribing vs continued use

Adverse drug withdrawal events ‐ esophagitis (endoscopic findings) · people with moderate GERD and mild esophagitis, mean age 48 to 57 years

On‐demand deprescribing may leads to higher adverse drug withdrawal events ‐ esophagitis (endoscopic findings) compared with continued use (low certainty).

1 finding from 1 review

Abrupt discontinuation deprescribing vs continued use

Adverse drug withdrawal events ‐ relapse (endoscopic findings) · people with mild to moderate esophagitis, symptomatic, aged > 18 years (mean age 73 years)

It is very uncertain whether abrupt discontinuation deprescribing changes adverse drug withdrawal events ‐ relapse (endoscopic findings) compared with continued use (very low certainty).

1 finding from 1 review

G‐CSF vs placebo or no treatment

Normalcy of diet (percutaneous endoscopic gastrostomy) · Adults with cancer receiving treatment

Granulocyte-colony stimulating factor (G-CSF) showed no clear difference in normalcy of diet (percutaneous endoscopic gastrostomy) compared with placebo or no treatment; GRADE not reported.

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: video‐assisted vs. endoscopic · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: video‐assisted vs. endoscopic (very low certainty).

1 finding from 1 review

Intervention not reported

Minimally invasive step‐up approach: video‐assisted vs. endoscopic · people with necrotising pancreatitis

It is very uncertain whether the intervention changes minimally invasive step‐up approach: video‐assisted vs. endoscopic (very low certainty).

1 finding from 1 review