new carious lesions or fillings · Children with dental caries in permanent (first) molars
The review reported no significant result for SDF; no effect estimate or GRADE rating was reported.
1 finding from 1 review
Streptococcus mutans acid (lactic acid) production and cariogenic potential · Oral biofilm of children/individuals at risk of dental caries
The review concludes that Veillonella spp. may modulate (often inhibit) S. mutans acid production and compete for lactate substrate, potentially reducing cariogenesis, but the evidence is narrative and ungraded.
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Compared with other caries-management methods, SDF may increase caries arrestment at the individual level, but the pooled estimate is very imprecise (low certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
In one trial, SDF greatly increased individual-level caries arrestment versus ART/glass ionomer cement (OR 18.03); this subgroup was not separately GRADE-rated.
1 finding from 1 review
Dental caries prevalence · Children (<18 years) with intellectual and developmental disabilities (IDD) in India
Dental caries affects about 64% of children with IDD in India (pooled prevalence 0.64, 95% CI 0.45-0.79; high heterogeneity; ungraded).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
In one trial, SDF increased tooth-level caries arrestment versus 5% sodium fluoride varnish (OR 4.75; ungraded subgroup).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two highly heterogeneous trials, SDF showed no significant difference versus 5% sodium fluoride varnish in surface-level caries arrestment (OR 1.46; ungraded subgroup).
1 finding from 1 review
Early childhood caries experience (mean dmft) · Nigerian children with primary dentition (approximately 6 months to 5 years)
In primary dentition, high-frequency sugar consumption was associated with slightly higher, non-significant odds of caries (OR 1.13, 95% CI 0.23 to 5.44), with high heterogeneity (I2=83%; ungraded).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably results in a slight increase in tooth-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Caries arrestment at the individual (patient) level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF markedly increased individual-level caries arrestment versus placebo (OR 18.10; ungraded subgroup).
1 finding from 1 review
Caries arrestment at the surface level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
SDF probably makes little to no difference to surface-level caries arrestment versus other methods (moderate certainty).
1 finding from 1 review
Dental caries prevalence · Nigerian individuals, including children and adults, with primary or permanent dentition
High-frequency sugar consumption was associated with 18% higher but non-significant odds of dental caries in Nigeria (OR 1.18, 95% CI 0.87 to 1.59; I2=36%; ungraded).
1 finding from 1 review
Caries arrestment at the tooth level · Children and adults with active dental caries (aged 1-50; mostly preschool/school children with primary dentition)
Pooling two trials, SDF and ART/glass ionomer cement showed no clear difference in tooth-level caries arrestment (OR 1.22, wide CI; ungraded subgroup).
1 finding from 1 review
Caries/restoration status in permanent molars · Children with dental caries in permanent (first) molars
SDF gave significantly better caries/restoration outcomes than ART over 9 months in children's permanent molars (p=0.004; ungraded).
1 finding from 1 review
Satyarup et al. (2022): 38% SDF vs ART; SDF group 5.6% carious teeth with partly lost restorations vs ART 16.7% carious with partly lost and 8.9% carious with completely lost restorations (p=0.004, favoring SDF).
1 study · 190 participants
GRADE not reported
New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars
NaF gave a 48% prevented fraction (fissure site) vs water (p<0.002; ungraded).
3 findings from 1 review
Prevented Fraction 48
1 study · 501 participants
GRADE not reported
Prevented Fraction 47
1 study · 141 participants
GRADE not reported
Prevented Fraction 41
1 study · 501 participants
GRADE not reported
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
ART within a brushing programme significantly reduced caries vs control (p<0.01; ungraded).
2 findings from 1 review
Mean new caries increment (surfaces) 0.01
1 study · 1016 participants
GRADE not reported
Mean new caries increment (surfaces) 0.06
1 study · 1016 participants
GRADE not reported
New coronal caries in permanent first molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time ammonium bifluoride gave a 56% prevented fraction, similar to SDF (57%) (single study; ungraded).
1 finding from 1 review
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time SDF within a brushing programme did not significantly reduce caries vs control (p>0.05; ungraded).
2 findings from 1 review
New coronal caries in permanent molars (caries prevention) · Children with dental caries in permanent (first) molars
Resin sealant gave a 65% prevented fraction (fissure site) vs water, the highest fissure-site value (p<0.002; ungraded).
2 findings from 1 review
New coronal carious lesions or fillings on permanent (first) molars (caries prevention) · Children with dental caries in permanent (first) molars
One-time 38% SDF gave a 57% prevented fraction for caries in children's permanent first molars (single study; ungraded).
1 finding from 1 review