Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing direct pulp capping
For direct pulp capping, MTA probably achieves higher clinical and radiographic success than calcium hydroxide (OR 3.10, 95% CI 1.66-5.79; moderate certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth of mixed/unspecified root maturation
In mixed-maturation teeth, the effect of MTA versus calcium hydroxide on success is very uncertain (OR 1.11, 95% CI 0.17-7.11; very low certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing pulpotomy
For pulpotomy, whether MTA improves success over calcium hydroxide is uncertain (OR 2.36, 95% CI 0.47-11.75; low certainty; CI includes no effect).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
Biodentine appeared to perform better than calcium hydroxide for success, but the evidence was not pooled (2 RCTs; ungraded).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in mature permanent teeth
In mature teeth, MTA probably achieves higher clinical and radiographic success than calcium hydroxide (OR 3.34, 95% CI 1.81-6.17; moderate certainty).
1 finding from 1 review
Overall success (composite of clinical and radiographic success) · Patients with carious pulp exposure in permanent teeth undergoing DPC or pulpotomy
MTA achieved higher clinical and radiographic success than calcium hydroxide overall (OR 2.94, 95% CI 1.96-4.49; low certainty), but this unadjusted estimate pools clinically heterogeneous DPC and pulpotomy studies.
1 finding from 1 review
Continued root formation / root development · Patients with carious pulp exposure in permanent teeth (predominantly immature) undergoing DPC or pulpotomy
Evidence on continued root formation for calcium hydroxide versus MTA is weak and inconclusive (3 RCTs, not pooled; ungraded).
1 finding from 1 review
Incidence: lung cancer · relatively healthy postmenopausal women
Vitamin D plus calcium showed no clear difference in incidence: lung cancer compared with placebo (low certainty).
1 finding from 1 review
Mortality: lung cancer · relatively healthy postmenopausal women
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Adverse events: renal calculi · relatively healthy postmenopausal women
Vitamin D plus calcium showed no clear difference in adverse events: renal calculi compared with placebo (moderate certainty).
1 finding from 1 review
Incidence: all cancers · relatively healthy postmenopausal women
Vitamin D plus calcium showed no clear difference in incidence: all cancers compared with placebo (low certainty).
1 finding from 1 review
Mortality: all cancers · relatively healthy postmenopausal women
Vitamin D plus calcium showed no clear difference in mortality: all cancers compared with placebo (moderate certainty).
1 finding from 1 review
Mortality: all causes · relatively healthy postmenopausal women
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) probably leads to higher radiological failure compared with formocresol (FC) (moderate certainty).
2 findings from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) may leads to higher clinical failure compared with formocresol (FC) (low certainty).
2 findings from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) showed no clear difference in radiological failure compared with ferric sulphate (FS) (low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) showed no clear difference in clinical failure compared with ferric sulphate (FS) (low certainty).
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) showed no clear difference in clinical failure compared with portland cement (PC); GRADE not reported.
1 finding from 1 review
Clinical failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) showed no clear difference in clinical failure compared with mineral trioxide aggregate (MTA) + sodium hypochlorite (NaOCl); GRADE not reported.
1 finding from 1 review
Radiological failure · Children with extensive decay involving the dental pulp in primary teeth
Calcium hydroxide (CH) led to higher radiological failure compared with portland cement (PC); GRADE not reported.
1 finding from 1 review