Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,121 questions · 2,186 findings · 242 reviews

No studies found 493 · 22.6%GRADE not reported 158 · 7.2%Very low 600 · 27.4%Low 474 · 21.7%Moderate 364 · 16.7%High 97 · 4.4%

Macrolide+tetracycline vs macrolides

Number of people experiencing one or more exacerbations, Drug resistance/microbial sensitivity (as reported by trialists), including emergence of atypical bacteria, Number of participants colonised with Pseudomonas aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Quinolone vs tetracycline

Quality of life Drug resistance/microbial sensitivity Serious adverse events Lung function Hospitalisations Adverse events/side effects Number of participants colonised with P aeruginosa · patients with chronic obstructive pulmonary disease

The review found no eligible studies for this question.

1 finding from 1 review

Doxycycline vs tetracycline

Treatment failure · adults with scrub typhus

It is very uncertain whether doxycycline changes treatment failure compared with tetracycline (very low certainty).

1 finding from 1 review

Rifampicin vs doxycycline

Resolution of fever within 48 hours · adults with scrub typhus

It is very uncertain whether rifampicin changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review