Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

2,543 questions · 2,589 findings · 168 reviews · Schizophrenia

No studies found 601 · 23.2%GRADE not reported 446 · 17.2%Very low 721 · 27.8%Low 505 · 19.5%Moderate 274 · 10.6%High 42 · 1.6%

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Global: Other adverse effects than tardive dyskinesia Self‐report by participants · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in global: Other adverse effects than tardive dyskinesia Self‐report by… compared with placebo (low certainty).

1 finding from 1 review

Pyridoxal 5 phosphate (vitamin B6) vs placebo

Tardive dyskinesia: Deterioration of symptoms · patients with antipsychotic‐induced tardive dyskinesia

Pyridoxal 5 phosphate (vitamin B6) showed no clear difference in tardive dyskinesia: Deterioration in tardive dyskinesia symptoms ESRS1 compared with placebo (low certainty).

1 finding from 1 review

Yoga vs usual care

Global state: no improvement ‐ medium termAs defined in each study · patients with schizophrenia

YOGA probably leads to lower mental state: Overall ‐ not improved PANSS compared with STANDARD CARE (moderate certainty).

1 finding from 1 review

Yoga vs usual care

Social functioning · patients with schizophrenia

YOGA showed no clear difference in social functioning: Overall ‐ not improved SOFS compared with STANDARD CARE (moderate certainty).

1 finding from 1 review

Yoga vs usual care

Mean change in quality of life at ≥ 12 months using the 36‐Item Short Form Health Survey mental component score (SF‐36 MCS) · patients with schizophrenia
1 finding from 1 review

Yoga vs usual care

Leaving the study early Leaving the study early: participants lost to · patients with schizophrenia

YOGA showed no clear difference in leaving the study early Leaving the study early: participants lost to compared with STANDARD CARE (moderate certainty).

1 finding from 1 review

Zuclopenthixol dihydrochloride vs placebo

Clinically significant response on global state · patients with schizophrenia

It is very uncertain whether ZUCLOPENTHIXOL DIHYDROCHLORIDE changes clinically significant response on global state ‐ as defined by each… compared with PLACEBO (very low certainty).

1 finding from 1 review