Findings

What do systematic reviews say?

2,511 questions · 2,668 findings · 290 reviews

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No studies found 743 · 27.8%GRADE not reported 329 · 12.3%Very low 775 · 29%Low 484 · 18.1%Moderate 279 · 10.5%High 58 · 2.2%

Extracorporeal shockwave therapy vs sham

Quality of life · men with Peyronie's disease (palpable plaque or pain)

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 130 participants
Low

Extracorporeal shockwave therapy vs sham

Treatment‐related adverse effects · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes treatment‐related adverse effects compared with sham (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 2.73 [0.74, 10.14]
3 studies · 166 participants
Very low

Extracorporeal shockwave therapy vs sham

Degree of penile curvature · men with Peyronie's disease (palpable plaque or pain)

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 166 participants
Low

Extracorporeal shockwave therapy vs sham

Treatment discontinuation · men with Peyronie's disease (palpable plaque or pain)

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes discontinuation from treatment compared with sham (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 0.57 [0.06, 5.65]
4 studies · 238 participants
Very low

Penile traction therapy vs no treatment (short‐term)

Outcomes ( · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Penile traction therapy vs no treatment (short‐term)

Patient‐reported ability to have intercourse · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Penile traction therapy vs no treatment (short‐term)

Quality of life · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 82 participants
Very low

Penile traction therapy vs no treatment (short‐term)

Treatment‐related adverse effects · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 90 participants
Very low

Penile traction therapy vs no treatment (short‐term)

Degree of penile curvature · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 89 participants
Very low

Potassium paraaminobenzoate vs placebo

Treatment discontinuation · men with acute (maximum of 12 months) Peyronie's disease with no prior treatment and no evidence of calcified plaques (pain during…

It is very uncertain whether potassium paraaminobenzoate changes discontinuation from treatment compared with placebo (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 1.36 [0.72, 2.58]
1 study · 103 participants
Very low

Penile traction therapy vs no treatment (short‐term)

Treatment discontinuation · men with Peyronie's disease (diagnosis of disease: varying, penile curvature: at least 30 degrees)

It is very uncertain whether penile traction therapy changes discontinuation from treatment compared with no treatment (short‐term) (very low certainty).

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
RR 0.86 [0.31, 2.36]
2 studies · 182 participants
Very low

Injectional interferon alpha‐2B vs Normal saline

Outcomes ( · men with chronic (≥ 12 months) Peyronie's disease (single plaque)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional interferon alpha‐2B vs Normal saline

Patient‐reported ability to have intercourse · men with chronic (≥ 12 months) Peyronie's disease (single plaque)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Injectional interferon alpha‐2B vs Normal saline

Quality of life · men with chronic (≥ 12 months) Peyronie's disease (single plaque)

The review found no eligible studies for this question.

1 finding from 1 review

Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ventilation tubes vs no treatment

Improvement in frequency of vertigo (complete resolution) at > 12 months · Ménière’s disease

It is very uncertain whether ventilation tubes changes improvement in frequency of vertigo (complete resolution) at > 12… compared with no treatment (very low certainty).

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
RR 1.55 [1.22, 1.97]
1 study · 133 participants
Very low

Ventilation tubes vs no treatment

Change in vertigo frequency · Ménière’s disease

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Ventilation tubes vs no treatment

Serious adverse events · Ménière’s disease

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Endolymphatic sac decompression vs placebo (sham surgery)

Improvement in vertigo (complete resolution) at 6 to ≤ 12 months (12 months) · Ménière’s disease

It is very uncertain whether endolymphatic sac decompression changes improvement in vertigo (complete resolution) at 6 to ≤ 12 months (12… compared with placebo (sham surgery) (very low certainty).

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
RR 1.3 [0.86, 1.96]
1 study · 30 participants
Very low

Endolymphatic sac decompression vs placebo (sham surgery)

Improvement in vertigo · Ménière’s disease

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
no estimate extracted
1 study · 29 participants
Very low

Endolymphatic sac decompression vs placebo (sham surgery)

Serious adverse events · Ménière’s disease

The review found no eligible studies for this question.

1 finding from 1 review

Surgical interventions for Ménière’s disease 2023 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found