Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,730 questions · 18,059 findings · 1,282 reviews

No studies found 4,360 · 24.1%GRADE not reported 2,529 · 14%Very low 4,641 · 25.7%Low 4,007 · 22.2%Moderate 2,057 · 11.4%High 465 · 2.6%

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Intrauterine infusion of autologous platelet‐rich plasma vs no intervention

Adverse events: ectopic pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine injection of autologous platelet‐rich plasma changes adverse events: ectopic pregnancy compared with no intervention (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Live birth or ongoing pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes live birth (or ongoing pregnancy) compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Miscarriage · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes miscarriage compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Clinical pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes clinical pregnancy compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse event ‐ multiple pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes adverse events: multiple pregnancy compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Intrauterine infusion/injection of autologous platelet‐rich plasma vs placebo or no intervention

Adverse events: ectopic pregnancy · women undergoing assisted reproduction

It is very uncertain whether intrauterine infusion/injection of autologous platelet‐rich plasma changes adverse events: ectopic pregnancy compared with no intervention or placebo (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

All‐cause mortality · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in all‐cause mortality compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Laboratory‐confirmed leptospirosis · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes laboratory‐confirmed leptospirosis compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis of infection regardless of laboratory confirmed · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis of infection regardless of laboratory confirmed compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Clinical diagnosis confirmed by laboratory diagnosis · farmworkers, soldiers, and people in endemic areas

Summary of findings table ‐ Antibiotics showed no clear difference in clinical diagnosis confirmed by laboratory diagnosis compared with placebo or no intervention (low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Non‐serious adverse events · farmworkers, soldiers, and people in endemic areas

It is very uncertain whether summary of findings table ‐ Antibiotics changes non‐serious adverse events compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

All‐cause mortality · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes all‐cause mortality compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Antibiotics vs placebo or no intervention

Adverse events considered non‐serious · people with leptospirosis

It is very uncertain whether summary of findings table ‐ Antibiotics changes adverse events considered non‐serious compared with placebo or no intervention (very low certainty).

1 finding from 1 review

Xylitol (low-intensity sweetener/sugar alcohol) in food products (chewing gum, milk, candy, or tablets) vs no intervention

Change in Mutans streptococci (MS) count in dental plaque · healthy people

Xylitol significantly reduced Mutans streptococci in dental plaque compared with no treatment (SMD -0.73, 95% CI -1.09 to -0.37; 5 trials, I2=53%; not GRADE-rated).

1 finding from 1 review

Silver diamine fluoride (SDF) vs Placebo, control, and/or other interventions

Caries arrestment at the tooth level · Children and adults without systemic diseases affecting dental health

SDF showed a higher caries-free proportion at the tooth level, but the reported difference was not statistically significant.

1 finding from 1 review

Er:YAG laser irradiation of enamel after demineralisation vs No anticaries intervention (untreated enamel)

Enamel surface microhardness · Demineralised / white-spot-lesion enamel (in vitro specimens)

In demineralised enamel, Er:YAG laser irradiation did not significantly change surface microhardness versus untreated control (SMD 0.66, 95% CI -1.12 to 2.44; 2 in vitro studies; ungraded).

1 finding from 1 review

Er:YAG laser irradiation of sound enamel before acid challenge vs No anticaries intervention (untreated enamel)

Enamel demineralization (QLF ΔF) · Human tooth enamel specimens, sound/intact (in vitro)

Er:YAG laser irradiation significantly reduced enamel mineral loss versus untreated control (SMD -2.09, 95% CI -3.29 to -0.88; 4 in vitro studies; ungraded).

1 finding from 1 review