What do systematic reviews say?

Summary of findings: Comparison 3 ‐ deferiprone (DFP) vs deferoxamine

It is very uncertain whether summary of findings: Comparison 1 ‐ deferiprone (DFP) changes total reported SAEs (from therapy, disease, non‐adherence) compared with deferoxamine (DFO) (very low certainty).

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  RR 1.43 [0.83, 2.46]
  1 study · 228 participants
  Very low

DFP and DFO vs DFP

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 369 participants
  Low

DFP and DFO vs deferoxamine

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  5 studies · 281 participants
  Low

DFP and DFO vs DFP and DFX

Summary of findings: Comparison 7 ‐ deferiprone (DFP) plus… may leads to lower adherence to iron chelation therapy rates (n, N) compared with DFP plus deferasirox (DFX) (low certainty).

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  RR 0.84 [0.72, 0.99]
  1 study · 96 participants
  Low

Deferasirox vs deferiprone (DFO)

• Interventions for improving adherence to iron chelation therapy in people with sickle cell disease or thalassaemia 2023 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 452 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• First‐line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• First‐line therapy for adults with advanced renal cell carcinoma: a systematic review and network meta‐analysis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Active cycle of breathing techniques plus routine treatment vs routine treatment alone

• Chest physiotherapy for pneumonia in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Very low

Osteopathic manipulative treatment (OMT) plus routine treatment vs placebo plus routine treatment

• Chest physiotherapy for pneumonia in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 333 participants
  Very low

Positive expiratory pressure plus routine treatment vs routine treatment alone

The review found no eligible studies for this question.

• Chest physiotherapy for pneumonia in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High‐frequency chest wall oscillation plus fibrobronchoscope alveolar lavage vs fibrobronchoscope alveolar lavage alone

The review found no eligible studies for this question.

• Chest physiotherapy for pneumonia in adults 2022 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Single component intervention vs control

Single component intervention showed no clear difference in adherence to pharmacotherapy: number of people completing treatment compared with control (low certainty).

• Interventions to improve adherence to pharmacological therapy for chronic obstructive pulmonary disease (COPD) 2021 · Cochrane Headline outcomes only
  OR 0.67 [0.22, 1.99]
  1 study · 55 participants
  Low

Multi‐component intervention vs control

Multi‐component intervention may leads to higher adherence to pharmacotherapy: number of people achieving adherence… compared with control (low certainty).

• Interventions to improve adherence to pharmacological therapy for chronic obstructive pulmonary disease (COPD) 2021 · Cochrane Headline outcomes only
  RR 1.37 [1.18, 1.59]
  4 studies · 446 participants
  Low

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

• Parenteral versus enteral fluid therapy for children hospitalised with bronchiolitis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 810 participants
  Moderate

Summary of findings table ‐ Enteral tube feeding vs intravenous fluids

Summary of findings table ‐ Enteral tube feeding probably leads to lower change in modality of fluid therapy compared with intravenous fluids (moderate certainty).

• Parenteral versus enteral fluid therapy for children hospitalised with bronchiolitis 2021 · Cochrane Headline outcomes only
  RR 0.52 [0.38, 0.71]
  1 study · 759 participants
  Moderate

Family therapy vs placebo

Comparison 7: Family therapy showed no clear difference in repetition of SH at post‐intervention compared with placebo (moderate certainty).

• Interventions for self‐harm in children and adolescents 2021 · Cochrane Headline outcomes only
  OR 1 [0.49, 2.07]
  2 studies · 191 participants
  Moderate

Nicotine replacement therapy vs control

Nicotine replacement therapy may leads to higher biochemically validated smoking cessation at the latest point in… compared with control (low certainty).

• Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
  RR 1.37 [1.08, 1.74]
  9 studies · 2336 participants
  Low

Nicotine replacement therapy vs control

Nicotine replacement therapy showed no clear difference in mean birthweight (g) compared with control (low certainty).

• Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
  MD 99.73
  7 studies · 2202 participants
  Low

Nicotine replacement therapy vs control

Nicotine replacement therapy showed no clear difference in miscarriage and spontaneous abortion compared with control (low certainty).

• Pharmacological interventions for promoting smoking cessation during pregnancy 2020 · Cochrane Headline outcomes only
  RR 1.6 [0.53, 4.83]
  5 studies · 1916 participants
  Low

Regimens containing quinolone vs regimens containing cephalosporin

It is very uncertain whether regimens containing quinolone changes adverse events: any antibiotic‐related adverse event leading to… compared with regimens containing cephalosporins (very low certainty).

• Antibiotic therapy for pelvic inflammatory disease 2020 · Cochrane Headline outcomes only
  RR 2.24 [0.52, 9.72]
  Studies not reported
  Very low