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Evidence found and GRADE certainty

2,016 questions · 2,067 findings · 222 reviews · Headline outcomes only

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No studies found 471 · 22.8%GRADE not reported 108 · 5.2%Very low 570 · 27.6%Low 458 · 22.2%Moderate 363 · 17.6%High 97 · 4.7%

Macrolides vs doxycycline

Treatment failure · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes treatment failure compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 48 hours · adults and adolescents with scrub typhus

It is very uncertain whether macrolides changes resolution of fever within 48 hours compared with doxycycline (very low certainty).

1 finding from 1 review

Macrolides vs doxycycline

Resolution of fever within 5 days · adults and adolescents with scrub typhus

Macrolides showed no clear difference in resolution of fever within 5 days compared with doxycycline (low certainty).

1 finding from 1 review

Intervention not reported

Case fatality at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in case fatality at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Poor functional outcome at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in poor functional outcome at the end of (moderate certainty).

1 finding from 1 review

Intervention not reported

Number of infections at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention leads to lower number of infections at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Number of UTIs at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention leads to lower number of UTIs at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Number of pneumonias at the end of · patients with acute ischaemic or haemorrhagic stroke

The intervention showed no clear difference in number of pneumonias at the end of (high certainty).

1 finding from 1 review

Intervention not reported

Death · children and adults with acute bacterial meningitis

The intervention showed no clear difference in death (moderate certainty).

1 finding from 1 review

Intervention not reported

Neurological disability · children and adults with acute bacterial meningitis

The intervention showed no clear difference in neurological disability (low certainty).

1 finding from 1 review

Intervention not reported

Hearing loss · children and adults with acute bacterial meningitis

The intervention probably leads to lower hearing loss (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: nausea, vomiting, diarrhoea · children and adults with acute bacterial meningitis

It is very uncertain whether the intervention changes adverse effects: nausea, vomiting, diarrhoea (very low certainty).

1 finding from 1 review

Intervention not reported

Adverse effects: gastrointestinal bleeding · children and adults with acute bacterial meningitis

The intervention showed no clear difference in adverse effects: gastrointestinal bleeding (moderate certainty).

1 finding from 1 review

Intramuscular ceftriaxone vs oral amoxicillin plus oral probenecid

Cure of gonococcal infection (microbiological culture) · pregnant women with gonorrhoea infection

It is very uncertain whether intramuscular ceftriaxone changes cure of gonococcal infection (microbiological culture) compared with oral amoxicillin plus oral probenecid (very low certainty).

1 finding from 1 review