Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,006 questions · 3,171 findings · 607 reviews · Headline outcomes only

No studies found 411 · 13%GRADE not reported 153 · 4.8%Very low 968 · 30.5%Low 897 · 28.3%Moderate 589 · 18.6%High 153 · 4.8%

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs psychological interventions

Drug or alcohol use, or both following treatment completion ‐ Individual‐based intervention · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
1 finding from 1 review

Non‐trauma‐focused psychological intervention for PTSD and SUD or PTSD only vs control intervention

Severity of PTSD symptoms · Individuals with post‐traumatic stress disorder and comorbid substance use disorder
2 findings from 1 review

Mosaicplasty vs microfracture

Function (all scores/instruments): intermediate term IKDC 2000 (version) score. Scale from: 0 to 100; higher scores = better function. · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes function (all scores/instruments): intermediate term IKDC 2000… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Function (all scores/instruments): long term Scale from: 0 to 100; higher scores = better function. · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes function (all scores/instruments): long term Scale from: 0 to 100;… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

QoL · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes quality of life: long‐term KOOS QOL score. Scale 0 to 100; higher… compared with microfracture (very low certainty).

1 finding from 1 review

Mosaicplasty vs microfracture

Pain North Americal Spine Society pain scores. Scale from: 0 to 100 (higher scores indicate less pain). · Adults with isolated cartilage defects (defect areas 1.0 cm2 to 6.0 cm2) of the knee

It is very uncertain whether mosaicplasty changes pain: long‐term KOOS Pain score. Scale 0 to 100; higher scores =… compared with microfracture (very low certainty).

1 finding from 1 review

Intervention not reported

Chlamydia prevalence (high risk population) Outcome was prevalence of positive chlamydia tests in repeated cross‐sectional surveys of women tested at sex venues after 4 years of intervention. · healthy adults

The intervention may leads to lower chlamydia prevalence (high risk population) Outcome was prevalence… (low certainty).

1 finding from 1 review