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Evidence found and GRADE certainty

2,327 questions · 2,494 findings · 87 reviews · Oral Health

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No studies found 450 · 18%GRADE not reported 1,487 · 59.6%Very low 385 · 15.4%Low 121 · 4.9%Moderate 50 · 2%High 1 · 0%

Thalidomide (systemic; 100 mg or 300 mg daily) vs placebo

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Males only
    Hamuryudan 1998: significant adverse effects including severe sedation, polyneuropathy, loss of libido, and weight gain; a greater number of adverse events was seen for the higher (300 mg) dose; 4 patients withdrew due…
    1 study · 101 participants
    GRADE not reported

One-stage augmentation (implants placed simultaneously) vs Two-stage augmentation (delayed implant placement)

Implant failure · Patients with insufficient bone below the maxillary sinus requiring dental implants

One-stage augmentation (implants placed simultaneously) showed no clear difference in implant failure compared with two-stage augmentation (delayed implant placement); GRADE not reported.

1 finding from 1 review

Osteotomes with mallet (Summers' technique) vs Rotary instruments (Cosci technique)

Complications · Patients undergoing crestal maxillary sinus lift

Osteotomes with mallet (Summers' technique) showed no clear difference in complications compared with rotary instruments (Cosci technique); GRADE not reported.

1 finding from 1 review

Sucralfate suspension (topical) vs Placebo suspension

Number of painful days · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care

Sucralfate suspension (topical) showed no clear difference in number of painful days compared with placebo suspension; GRADE not reported.

1 finding from 1 review

One-stage lateral sinus lift with monocortical autogenous bone blocks (iliac crest) vs Two-stage lateral sinus lift with autogenous particulate bone (iliac crest)

Prosthesis failure · Patients with 2 to 7 mm of residual alveolar bone height in the edentulous maxillary sinus floor

One-stage lateral sinus lift with monocortical autogenous bone… showed no clear difference in prosthesis failure compared with two-stage lateral sinus lift with autogenous particulate bone (iliac…; GRADE not reported.

1 finding from 1 review

Sinus lift with bone graft (granular Bio-Oss) vs Sinus lift without bone graft (Inion resorbable rigid barrier maintaining space / no bone)

Complications · Patients with an atrophic maxillary sinus requiring augmentation (1 to 5 mm residual bone height)

Sinus lift with bone graft (granular Bio-Oss) showed no clear difference in complications compared with sinus lift without bone graft (Inion resorbable rigid barrier…; GRADE not reported.

1 finding from 1 review

Hand mallet (osteotomes) vs Electric mallet

Complication at augmented site · Patients undergoing one-stage crestal maxillary sinus lift without bone grafts (baseline residual bone height about 6.5 mm)

Hand mallet (osteotomes) showed no clear difference in complications at augmented site compared with electric mallet; GRADE not reported.

1 finding from 1 review

Autogenous bone graft (two-stage lateral sinus lift) vs Bone substitute (anorganic bovine bone / Bio-Oss)

Implant failure · Patients with an atrophic posterior maxilla requiring maxillary sinus augmentation

Autogenous bone graft (two-stage lateral sinus lift) showed no clear difference in implant failure compared with bone substitute (anorganic bovine bone / Bio-Oss); GRADE not reported.

1 finding from 1 review

Bone graft with platelet-rich plasma (PRP) vs Bone graft without PRP

Implant failure · Patients with insufficient bone below the maxillary sinus requiring dental implants
1 finding from 1 review

Sinus lift with bone graft (granular Bio-Oss) vs Sinus lift without bone graft (Inion resorbable rigid barrier maintaining space / no bone)

Augmentation procedure failure · Patients with an atrophic maxillary sinus requiring augmentation (1 to 5 mm residual bone height)

Sinus lift with bone graft (granular Bio-Oss) showed no clear difference in augmentation procedure failure compared with sinus lift without bone graft (Inion resorbable rigid barrier…; GRADE not reported.

1 finding from 1 review

Thalidomide (systemic; 100 mg or 300 mg daily) vs placebo

Number of (minor aphthous) oral ulcers · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Males only
    Hamuryudan 1998 (thalidomide 100 mg or 300 mg daily vs placebo, 101 male patients; high risk of reporting bias): a significant effect on mean numbers of minor oral ulcers was reported from week 4 in both thalidomide…
    1 study · 101 participants
    GRADE not reported

Rotary instruments to open the lateral sinus window vs Piezosurgery to open the lateral sinus window

Complication at augmented site · Patients undergoing lateral-window maxillary sinus lift

Rotary instruments to open the lateral sinus window showed no clear difference in complications at augmented site compared with piezosurgery to open the lateral sinus window; GRADE not reported.

1 finding from 1 review

Cyclosporin A in orabase (topical) vs Placebo (orabase)

Oral ulcers (number, size, healing time) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Ergun 1997 (cyclosporin A in orabase vs placebo orabase, 24 patients; high risk of reporting bias): no data were presented; authors reported no clinical improvement in the number, size, and healing time of ulcers for…
    1 study · 24 participants
    GRADE not reported

One-stage augmentation (implants placed simultaneously) vs Two-stage augmentation (delayed implant placement)

Prosthesis failure · Patients with insufficient bone below the maxillary sinus requiring dental implants

One-stage augmentation (implants placed simultaneously) showed no clear difference in prosthesis failure compared with two-stage augmentation (delayed implant placement); GRADE not reported.

1 finding from 1 review

Interferon-alpha (systemic) vs Placebo (subcutaneous)

Safety of the intervention (adverse effects) · People with Behcet's disease with a history of recurrent oral aphthous-type (RAS-type) ulcers diagnosed clinically; primary care
1 finding from 1 review
  • Interventions for managing oral ulcers in Behçet's disease 2014 · Cochrane All outcomes
    Alpsoy 2002: high rate of adverse events including alopecia, leukopenia, and diarrhoea; 18 of 23 patients in the treatment arm experienced mild flu-like symptoms.
    1 study · 50 participants
    GRADE not reported

Bio-Oss (anorganic bovine bone) vs A different bone substitute

Complication at augmented site · Patients undergoing two-stage maxillary sinus augmentation

Bone substitute (anorganic bovine bone / Bio-Oss) showed no clear difference in complications at augmented site compared with A different bone substitute; GRADE not reported.

1 finding from 1 review