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Each row is one question a systematic review asked: who, what, compared with what, and which outcome, with the effect it found and how certain that is. Words match anywhere in the field.
1,645 questions in 107 reviews · Wounds
current versionsNo studies 651 · 39.6%Ungraded 84 · 5.1%Very low 554 · 33.7%Low 283 · 17.2%Moderate 64 · 3.9%High 9 · 0.5%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
| Question | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Distilled water vs cooled boiled water Healing rate · people with fractures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Distilled water vs cooled boiled water Cost analysis · people with fractures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Distilled water vs cooled boiled water Pain · people with fractures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Distilled water vs cooled boiled water Patient satisfaction · people with fractures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Tap water vs no wound cleansing Healing rate · people with anal fissures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Tap water vs no wound cleansing Cost analysis · people with anal fissures Water for wound cleansing (2022) · Cochrane | no estimate extracted | NR | No studies |
Tap water vs no wound cleansing Pain · people with anal fissures Water for wound cleansing (2022) · Cochrane | no estimate extracted | 1 study · 52 participants | Low |
Tap water vs no wound cleansing Patient satisfaction · people with anal fissures Water for wound cleansing (2022) · Cochrane | no estimate extracted | 2 studies · 102 participants | Low |
Tap water vs normal saline Infection · people with acute and chronic wounds Water for wound cleansing (2022) · Cochrane | RR 0.84 [0.59, 1.19] | 8 studies · 2204 participants | Very low |
Tap water vs normal saline Wounds healed · people with acute and chronic wounds Water for wound cleansing (2022) · Cochrane | RR 0.57 [0.3, 1.07] | 2 studies · 79 participants | Very low |
Negative pressure wound therapy vs standard dressing Mortality (proportion of participants dying in each group at · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 0.78 [0.47, 1.3] | 11 studies · 6384 participants | Low |
Negative pressure wound therapy vs standard dressing Surgical site infection (proportion of participants in each group with SSI; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 0.73 [0.63, 0.85] | 44 studies · 11403 participants | Moderate |
Negative pressure wound therapy vs standard dressing Dehiscence (proportion of participants in each group with wound dehiscence; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 0.97 [0.82, 1.16] | 23 studies · 8724 participants | Moderate |
Negative pressure wound therapy vs standard dressing Reoperation (proportion of participants in each group requiring reoperation for reasons related to wound; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | no estimate extracted | 18 studies · 6272 participants | Low |
Negative pressure wound therapy vs standard dressing Seroma (proportion of participants in each group with seroma; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 0.82 [0.65, 1.05] | 15 studies · 5436 participants | Low |
Negative pressure wound therapy vs standard dressing Haematoma (proportion of participants in each group with haematoma; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 0.79 [0.48, 1.3] | 17 studies · 5909 participants | Very low |
Negative pressure wound therapy vs standard dressing Skin blisters (proportion of participants in each group with at least one skin blister; · adult patients with surgical wounds healing by primary closure Negative pressure wound therapy for surgical wounds healing by primary closure (2022) · Cochrane | RR 3.55 [1.43, 8.77] | 11 studies · 5015 participants | Low |
Hydrogel dressings vs gauze and saline Complete wound healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | RR 5.33 [1.73, 16.42] | 1 study · 60 participants | Very low |
Hydrogel dressings vs alginate gel Time‐to‐ulcer healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs alginate gel Health‐related quality of life · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs alginate gel Costs · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs manuka honey Complete wound healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | RR 0.75 [0.46, 1.21] | 1 study · 108 participants | Very low |
Hydrogel dressings vs manuka honey Incidence of wound infection · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | RR 2 [0.81, 4.94] | 1 study · 108 participants | Very low |
Hydrogel dressings vs manuka honey Change in ulcer size · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs manuka honey Time‐to‐ulcer healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs manuka honey Health‐related quality of life · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs manuka honey Costs · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressing vs hydrocolloid Complete ulcer healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs gauze and saline Incidence of wound infection · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressing vs hydrocolloid Incidence of wound infection · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressing vs hydrocolloid Change in ulcer size · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | 1 study · 84 participants | Very low |
Hydrogel dressing vs hydrocolloid Time‐to‐ulcer healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressing vs hydrocolloid Health‐related quality of life · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressing vs hydrocolloid Costs · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs gauze and saline Changes in ulcer size (cm²) · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | MD 1.5 | 1 study · 60 participants | Very low |
Hydrogel dressings vs gauze and saline Time‐to‐ulcer healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs gauze and saline Health‐related quality of life · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs gauze and saline Costs · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs alginate gel Complete wound healing · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs alginate gel Incidence of wound infection · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | no estimate extracted | NR | No studies |
Hydrogel dressings vs alginate gel Change in ulcer size: percent reduction in ulcer area at 4 weeks · people with venous leg ulcers Hydrogel dressings for venous leg ulcers (2022) · Cochrane | MD 41.8 | 1 study · 20 participants | Very low |
Laser therapy vs no treatment Scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus no treatment ‐ patient self‐assessment of scar improvement of 50% or higher ‐ hypertrophic and keloid scars ‐ · patients with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | RR 1.96 [1.11, 3.45] | NR | Low |
Laser therapy vs no treatment Scar severity ‐ Fractional CO2 Laser versus no treatment ‐ VBS (higher scores = worse scar appearance) ‐ keloid scars ‐ · patients with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | no estimate extracted | NR | Very low |
Laser therapy vs no treatment Scar severity ‐ Fractional CO2 Laser versus no treatment ‐ POSAS scale (higher scores = worse scar appearance) ‐ hypertrophic scars ‐ · patients with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | no estimate extracted | NR | Very low |
Laser therapy vs other treatments Scar severity ‐ 585‐nm Pulsed‐Dye Laser (PDL) versus Triamcinolone acetonide (TAC) ‐ Vancouver Burn Scar (VBS) (Higher score = worse scar appearance) ‐ hypertrophic scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | no estimate extracted | NR | Very low |
Laser therapy vs other treatments Scar severity ‐ 585‐nm PDL versus TAC ‐ patient self‐assessment of scar improvement of 50% or higher, or patients considering the scar better or much better ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | OR 0.81 | NR | Very low |
Laser therapy vs other treatments Incidence and severity of treatment‐related adverse effects ‐ 585‐nm PDL versus TAC: sequelae ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | RR 0.09 [0.01, 1.45] | NR | Very low |
Laser therapy vs other treatments Incidence and severity of treatment‐related adverse effects ‐ 585‐nm PDL versus TAC ‐ mild to moderate pain related to treatment ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | RR 0.9 | NR | Very low |
Laser therapy vs other treatments Scar severity ‐ 585‐nm PDL versus 5‐FU ‐ patient self‐assessment of scar improvement of 50% or higher ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | OR 0.81 | NR | Very low |
Laser therapy vs other treatments Incidence and severity of treatment‐related adverse effects ‐ 585‐nm PDL versus 5‐FU ‐ mild to moderate pain related to treatment ‐ hypertrophic and keloid scars ‐ · participants with hypertrophic and keloid scars Laser therapy for treating hypertrophic and keloid scars (2022) · Cochrane | RR 0.9 | NR | Very low |