Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

327 questions · 337 findings · 47 reviews · Headline outcomes only

No studies found 69 · 20.5%GRADE not reported 35 · 10.4%Very low 49 · 14.5%Low 73 · 21.7%Moderate 63 · 18.7%High 48 · 14.2%

Intervention not reported

Behavioural outcome: colorectal cancer screening IVR versus usual care at 6‐month · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention probably leads to higher behavioural outcome: colorectal cancer screening IVR versus usual… (moderate certainty).

1 finding from 1 review

Intervention not reported

Behavioural outcome: colorectal cancer screening IVR, unidirectional ATCS versus usual care or letter at longer (9‐12 months) · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The intervention showed no clear difference in behavioural outcome: colorectal cancer screening IVR, unidirectional… (moderate certainty).

1 finding from 1 review

Summary of findings: multimedia education vs no education or usual care

Health outcomes: Drug misuse and dependence CAGE screening tool. Scale from 0 to 4. Higher score indicates greater probability of drug misuse or dependence · patients taking prescribed and over‐the‐counter medications or their carers
1 finding from 1 review

Intervention not reported

Perception ‐ screening message (measured as rating on a scale of perceived effectiveness) · consumers
1 finding from 1 review

Intervention not reported

Persuasiveness ‐ screening message (measured as a hypothetical decision or intention or willingness to adopt an intervention) · consumers
1 finding from 1 review

Decision aids for informed consent vs usual care

Congruence between informed values and choice ‐ all studies Based on the proportion of participants who made a decision that aligned with what was most important to them. Assessed soon after exposure to the decision aid. · adults considering treatment or screening decisions

Patient decision aids probably leads to higher congruence between informed values and choice ‐ all studies Based on… compared with usual care (moderate certainty).

1 finding from 1 review

Decision aids for informed consent vs usual care

Participation in decision making: clinician‐controlled decision making ‐ all studies Assessed soon after consultation with clinician · adults considering treatment or screening decisions

Patient decision aids leads to lower participation in decision‐making: clinician‐controlled… compared with usual care (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental cancer detection in women with dense breasts: cohort studies · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental cancer detection in women with dense breasts: RCT compared with mammography alone (high certainty).

2 findings from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Incremental detection of invasive cancers · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in incremental detection of invasive cancers compared with mammography alone (low certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

Interval cancer · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography showed no clear difference in interval cancer compared with mammography alone (high certainty).

1 finding from 1 review

Mammography in combination with breast ultrasonography vs mammography alone

False‐positive rate in women with dense breasts · breast cancer screening in women at average risk with dense breasts

Mammography in combination with breast ultrasonography leads to higher false‐positive rate in women with dense breasts compared with mammography alone (high certainty).

1 finding from 1 review