Treatment failure within 72 hours of trial entry · preterm infants requiring primary respiratory support
Nasal high flow probably leads to higher treatment failure within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).
1 finding from 1 review
Mechanical ventilation within 72 hours of trial entry · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in mechanical ventilation within 72 hours of trial entry compared with continuous positive airway pressure (moderate certainty).
1 finding from 1 review
Pneumothorax · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in pneumothorax (during assigned treatment) compared with continuous positive airway pressure (moderate certainty).
1 finding from 1 review
Nasal trauma (during assigned treatment) · preterm infants requiring primary respiratory support
Nasal high flow probably leads to lower nasal trauma (during assigned treatment) compared with continuous positive airway pressure (moderate certainty).
1 finding from 1 review
Death (before hospital discharge) or BPD (supplemental oxygen/respiratory support at 36 weeks' postmenstrual age if born < 32 weeks' gestation, or 28 days if born ≥ 32 weeks' gestation) · preterm infants requiring primary respiratory support
It is very uncertain whether nasal high flow changes death (before hospital discharge) or BPD (supplemental… compared with nasal intermittent positive pressure ventilation (very low certainty).
1 finding from 1 review
Mortality before hospital discharge · preterm infants requiring primary respiratory support
Nasal high flow showed no clear difference in death (before hospital discharge) compared with nasal intermittent positive pressure ventilation (low certainty).
1 finding from 1 review
Neonatal mortality · preterm infants at risk of respiratory distress syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Mortality before hospital discharge · preterm infants at risk of respiratory distress syndrome
It is very uncertain whether surfactant treatment guided by rapid tests for surfactant deficiency changes mortality prior to hospital discharge№ of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (very low certainty).
1 finding from 1 review
RR 1.25 [0.65, 2.41]
Studies not reported
Very low
Bronchopulmonary dysplasia · preterm infants at risk of respiratory distress syndrome
Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in bronchopulmonary dysplasia№ of participants: 562(3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).
1 finding from 1 review
RR 0.9 [0.61, 1.32]
Studies not reported
Low
Bronchopulmonary dysplasia or mortality ‐ not reported · preterm infants at risk of respiratory distress syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Surfactant utilization № of participants: 562 (3 RCTs) · preterm infants at risk of respiratory distress syndrome
Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in surfactant utilization № of participants: 562 (3 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).
1 finding from 1 review
RR 0.97 [0.85, 1.11]
Studies not reported
Low
Pneumothorax · preterm infants at risk of respiratory distress syndrome
Surfactant treatment guided by rapid tests for surfactant deficiency showed no clear difference in any pneumothorax№ of participants: 506(2 RCTs) compared with surfactant therapy provided to preterm infants with respiratory… (low certainty).
1 finding from 1 review
RR 0.53 [0.15, 1.92]
Studies not reported
Low
Neurodevelopmental outcomes · preterm infants at risk of respiratory distress syndrome
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proven catheter‐related bloodstream infection (CRBSI) expressed by the authors of the individual trial as absolute rates · neonates that require central line
CHG‐IPA showed no clear difference in proven catheter‐related bloodstream infection (CRBSI) expressed by… compared with PI (low certainty).
1 finding from 1 review
Premature central line removal, defined as number of central venous catheters (CVC) removed in the trial as deemed by the author as the source of infection (premature central line removal) · neonates that require central line
CHG‐IPA showed no clear difference in premature central line removal, defined as number of central venous… compared with CHG‐A (moderate certainty).
1 finding from 1 review
Central line‐associated bloodstream infection (CLABSI) expressed using absolute rates of infants · neonates that require central line
It is very uncertain whether CHG‐IPA changes central line‐associated bloodstream infection (CLABSI) expressed… compared with PI (very low certainty).
1 finding from 1 review
Premature central line removal, defined as number of central venous catheters (CVC) removed in the trial as deemed by the author as the source of infection (premature central line removal) · neonates that require central line
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Proven catheter‐related bloodstream infection (CRBSI) expressed by the authors of the individual trial as absolute rates · neonates that require central line
CHG‐IPA showed no clear difference in proven catheter‐related bloodstream infection (CRBSI) expressed by… compared with CHG‐A (low certainty).
1 finding from 1 review
Central‐line associated bloodstream infection (CLABSI) expressed by the authors of the individual trial as absolute rates · neonates that require central line
CHG‐IPA showed no clear difference in central‐line associated bloodstream infection (CLABSI) expressed by… compared with CHG‐A (low certainty).
1 finding from 1 review
Positive‐pressure ventilation after institution of treatment · treatment of apnea
It is very uncertain whether doxapram changes 2a. Need for positive pressure ventilation after initiation of… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty).
3 findings from 1 review