Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or: Positive‐pressure ventilation after institution of treatment
- Population
- treatment of apnea
- Intervention
- Doxapram
- Comparison
- no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or
- Outcome
- Positive‐pressure ventilation after institution of treatment
It is very uncertain whether doxapram changes 2a. Need for positive pressure ventilation after initiation of… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or 2a. Need for positive pressure ventilation after initiation of treatment – doxapram compared to no treatment for the treatment of apnea · treatment of apnea It is very uncertain whether doxapram changes 2a. Need for positive pressure ventilation after initiation of… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty). Doxapram for the prevention and treatment of apnea in preterm infants (2023) · Cochrane Headline outcomes only | RR 0.31 [0.01, 6.74] | 1 study · 21 participants | Very low |
Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or 2b. Need for positive pressure ventilation after initiation of treatment – doxapram compared to alternative treatment for the treatment of apnea · treatment of apnea It is very uncertain whether doxapram changes 2b. Need for positive pressure ventilation after initiation of… compared with no treatment, placebo, methylxanthine (including theophylline,… (very low certainty). Doxapram for the prevention and treatment of apnea in preterm infants (2023) · Cochrane Headline outcomes only | RR 2.4 [0.11, 51.32] | 2 studies · 37 participants | Very low |
Doxapram vs no treatment, placebo, methylxanthine (including theophylline, aminophylline, or caffeine), or 2c. Need for positive pressure ventilation after initiation of treatment – doxapram as an adjunct to methylxanthine compared to methylxanthine alone for the treatment of apnea · treatment of apnea The review found no eligible studies for this question. Doxapram for the prevention and treatment of apnea in preterm infants (2023) · Cochrane Headline outcomes only | no estimate extracted | Not reported | No studies found |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Doxapram for the prevention and treatment of apnea in preterm infants 2023 · Cochrane Headline outcomes only | Not reported | Not extracted | Not assessed |
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.