Myocardial infarction · adult patients with hypertension
Lower BP target may leads to lower myocardial infarction№ of participants: 38,198(8 RCTs) compared with standard BP target (low certainty).
1 finding from 1 review
RR 0.84 [0.73, 0.96]
Studies not reported
Low
Stroke · adult patients with hypertension
Lower BP target showed no clear difference in stroke№ of participants: 37,087(7 RCTs) compared with standard BP target (low certainty).
1 finding from 1 review
RR 0.88 [0.77, 1.01]
Studies not reported
Low
Congestive heart failure · adult patients with hypertension
Lower BP target may leads to lower congestive heart failure№ of participants: 15,859(5 RCTs) compared with standard BP target (low certainty).
1 finding from 1 review
RR 0.75 [0.6, 0.92]
Studies not reported
Low
Other serious adverse events · adult patients with hypertension
Lower BP target may leads to higher other serious adverse events compared with standard BP target (low certainty).
1 finding from 1 review
RR 1.44 [1.32, 1.59]
Studies not reported
Low
Variation in the decrease in 24‐hour ambulatory hourly SBP (at 3 to 12 weeks) · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
no estimate extracted
121 participants
Very low
Variation in the decrease in 24‐hour ambulatory hourly DBP (at 3 to 12 weeks) · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
no estimate extracted
121 participants
Very low
Variation in the decrease in 24‐hour ambulatory hourly HR (at 3 to 12 weeks) · Men and non‐pregnant women ≥ 18 years old with essential hypertension
1 finding from 1 review
no estimate extracted
71 participants
Very low
Heart rate · adult participants
3 findings from 1 review
Heart rate · adult participants
1 finding from 1 review
Heart rate · adult participants
3 findings from 1 review
Intervention not reported
Systolic BP ‐ Aliskiren 75 mg vs. placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Systolic BP ‐ Aliskiren 150 mg vs. placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Systolic BP ‐ Aliskiren 300 mg vs. placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Systolic BP ‐ Aliskiren 600 mg vs. placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Diastolic BP ‐ Aliskiren 75 mg vs placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Diastolic BP ‐ Aliskiren 150 mg vs placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Diastolic BP ‐ Aliskiren 300 mg vs placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Diastolic BP ‐ Aliskiren 600 mg vs placebo · primary hypertension
1 finding from 1 review
Intervention not reported
Diarrhoea ‐ Aliskiren 600 mg vs placebo · primary hypertension
The intervention may leads to higher diarrhoea ‐ Aliskiren 600 mg vs placebo (low certainty).
1 finding from 1 review
Intervention not reported
Withdrawals due to adverse effects · adults with or without hypertension
1 finding from 1 review