Cochrane · systematic review · CD007066
Blood pressure lowering efficacy of renin inhibitors for primary hypertension
Musini, VM, Lawrence, KAK, Fortin, PM, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
HypertensionAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
9
current version
GRADE rated
9
No studies
0
Included studies
NR
No studies 0 · 0%Ungraded 0 · 0%Very low 0 · 0%Low 3 · 33.3%Moderate 6 · 66.7%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Comparison
Population: primary hypertension
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Systolic BP ‐ Aliskiren 75 mg vs. placebo | no estimate extracted | 5 studies · 1100 participants | Moderate Downgraded: risk of bias, imprecision |
Systolic BP ‐ Aliskiren 150 mg vs. placebo | no estimate extracted | 12 studies · 3786 participants | Moderate Downgraded: risk of bias, imprecision |
Systolic BP ‐ Aliskiren 300 mg vs. placebo | no estimate extracted | 10 studies · 3009 participants | Moderate Downgraded: risk of bias, imprecision |
Systolic BP ‐ Aliskiren 600 mg vs. placebo | no estimate extracted | 2 studies · 393 participants | Low Downgraded: risk of bias, imprecision |
Diastolic BP ‐ Aliskiren 75 mg vs placebo | no estimate extracted | 5 studies · 1100 participants | Moderate Downgraded: risk of bias, imprecision |
Diastolic BP ‐ Aliskiren 150 mg vs placebo | no estimate extracted | 12 studies · 3783 participants | Moderate Downgraded: risk of bias, imprecision |
Diastolic BP ‐ Aliskiren 300 mg vs placebo | no estimate extracted | 10 studies · 3001 participants | Moderate Downgraded: risk of bias, imprecision |
Diastolic BP ‐ Aliskiren 600 mg vs placebo | no estimate extracted | 2 studies · 393 participants | Low Downgraded: risk of bias, imprecision |
Diarrhoea ‐ Aliskiren 600 mg vs placebo | RR 7 [2.48, 19.72] | 2 studies · 592 participants | Low Downgraded: risk of bias, imprecision |