Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

166 questions · 178 findings · 15 reviews

No studies found 52 · 29.2%GRADE not reported 1 · 0.6%Very low 44 · 24.7%Low 56 · 31.5%Moderate 24 · 13.5%High 1 · 0.6%

Intervention not reported

Incidence of a secondary primary breast cancer (e.g. in the contralateral breast) ‐ endocrine therapies not separated (exemestane (AI)/tamoxifen (SERM)/unknown) · women receiving endocrine therapy (selective oestrogen receptor modulator or aromatase inhibitor)
1 finding from 1 review

Raloxifene vs placebo

Adverse events ‐ pelvic pain · women with endometriosis, following complete surgical excision of lesions

It is very uncertain whether raloxifene changes adverse events ‐ pelvic pain compared with placebo (very low certainty).

1 finding from 1 review

Raloxifene vs placebo

Adverse events ‐ ovarian cyst · women with endometriosis, following complete surgical excision of lesions

It is very uncertain whether raloxifene changes adverse events ‐ ovarian cyst compared with placebo (very low certainty).

1 finding from 1 review

Raloxifene vs placebo

Adverse events ‐ depression · women with endometriosis, following complete surgical excision of lesions

It is very uncertain whether raloxifene changes adverse events ‐ depression compared with placebo (very low certainty).

1 finding from 1 review

Raloxifene vs placebo

Biopsy‐proven recurrence of endometriosis · women with endometriosis, following complete surgical excision of lesions

It is very uncertain whether raloxifene changes biopsy‐proven recurrence of endometriosis compared with placebo (very low certainty).

1 finding from 1 review

Combined oral contraceptive pill vs no pretreatment

Live birth or ongoing pregnancy · women undergoing assisted reproduction

Combined oral contraceptive pill probably leads to lower live birth or ongoing pregnancy (COCP + Ant vs Ant) compared with no pretreatment (moderate certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Live birth or ongoing pregnancy · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in live birth or ongoing pregnancy (Prog + Ant vs Ant) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Pregnancy loss · ovarian stimulation protocols for women undergoing ART

Progestogen showed no clear difference in pregnancy loss (Prog + Ag vs Ag) compared with placebo or no pretreatment (low certainty).

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

Multiple pregnancy rate · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Summary of findings table ‐ Progestogens vs placebo or no pretreatment

OHSS · ovarian stimulation protocols for women undergoing ART

The review found no eligible studies for this question.

2 findings from 1 review

Combined oral contraceptive pill vs no pretreatment

Pregnancy loss · women undergoing assisted reproduction

Combined oral contraceptive pill showed no clear difference in pregnancy loss (COCP + Ant vs Ant) compared with no pretreatment (moderate certainty).

2 findings from 1 review

Combined oral contraceptive pill vs no pretreatment

Multiple pregnancy rate · women undergoing assisted reproduction

Combined oral contraceptive pill showed no clear difference in multiple pregnancy rate (COCP + Ant vs Ant) compared with no pretreatment (low certainty).

2 findings from 1 review