Cochrane · systematic review · CD006109
Oral contraceptive pill, progestogen or oestrogen pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques
Farquhar, C, Rombauts, L, Kremer, JAM, et al. · Cochrane Database of Systematic Reviews · 2017 · Cochrane Library
Gynaecology and FertilityAMSTAR 2: not assessed
SoF tableOnly the outcomes this review put in its Summary of Findings table are listed (the Cochrane Handbook caps them at about seven per comparison). Its other analyses are not shown here.
Questions
24
current version
GRADE rated
19
No studies
5
Included studies
NR
No studies 5 · 20.8%Ungraded 0 · 0%Very low 5 · 20.8%Low 8 · 33.3%Moderate 6 · 25%High 0 · 0%
Ungraded means an effect was reported without a GRADE rating; it is not a gap. No studies means the review found nothing to answer the question. The six categories are a display order, not a score.
Questions and results
Combined oral contraceptive pill compared to no pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques
Population: women undergoing ART
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy (COCP + Ant vs Ant) Combined oral contraceptive pill vs no pretreatment | OR 0.74 [0.58, 0.95] | 6 studies · 1335 participants | Moderate Downgraded: risk of bias |
Live birth or ongoing pregnancy (COCP + Ant vs Ag) Combined oral contraceptive pill vs no pretreatment | OR 0.89 [0.64, 1.25] | 4 studies · 724 participants | Moderate Downgraded: imprecision |
Pregnancy loss (COCP + Ant vs Ant) Combined oral contraceptive pill vs no pretreatment | OR 1.36 [0.82, 2.26] | 5 studies · 868 participants | Moderate Downgraded: imprecision |
Pregnancy loss (COCP + Ant vs Ag) Combined oral contraceptive pill vs no pretreatment | OR 0.4 [0.22, 0.72] | 5 studies · 780 participants | Moderate Downgraded: imprecision |
Multiple pregnancy rate (COCP + Ant vs Ant) Combined oral contraceptive pill vs no pretreatment | OR 2.21 [0.53, 9.26] | 2 studies · 125 participants | Low Downgraded: imprecision |
Multiple pregnancy rate (COCP + Ant vs Ag) Combined oral contraceptive pill vs no pretreatment | OR 1.36 [0.85, 2.19] | 4 studies · 546 participants | Moderate Downgraded: imprecision |
OHSS rate (COCP + Ant vs Ant) Combined oral contraceptive pill vs no pretreatment | OR 0.98 [0.28, 3.4] | 2 studies · 642 participants | Low Downgraded: imprecision |
OHSS rate (COCP + Ant vs Ag) Combined oral contraceptive pill vs no pretreatment | OR 0.63 [0.2, 1.96] | 2 studies · 290 participants | Low Downgraded: imprecision |
Progestogen compared to placebo or no pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques
Population: ovarian stimulation protocols for women undergoing ART
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy (Prog + Ag vs Ag) Progestogen vs placebo or no pretreatment | OR 1.35 [0.69, 2.65] | 2 studies · 222 participants | Low Downgraded: imprecision |
Live birth or ongoing pregnancy (Prog + Ant vs Ant) Progestogen vs placebo or no pretreatment | OR 0.67 [0.18, 2.54] | 1 study · 47 participants | Low Downgraded: imprecision |
Pregnancy loss (Prog + Ag vs Ag) Progestogen vs placebo or no pretreatment | OR 2.26 [0.67, 7.55] | 2 studies · 222 participants | Low Downgraded: imprecision |
Pregnancy loss (Prog + Ant vs Ant) Progestogen vs placebo or no pretreatment | OR 0.36 [0.06, 2.09] | 1 study · 47 participants | Low Downgraded: imprecision |
Multiple pregnancy rate (Prog + Ag vs Ag) Progestogen vs placebo or no pretreatment | no estimate extracted | NR | No studies |
Multiple pregnancy rate (Prog + Ant vs Ant) Progestogen vs placebo or no pretreatment | OR 1.05 [0.06, 17.76] | 1 study · 47 participants | Low Downgraded: imprecision |
OHSS rate (Prog + Ag vs Ag) Progestogen vs placebo or no pretreatment | no estimate extracted | NR | No studies |
OHSS rate (Prog + Ant vs Ant) Progestogen vs placebo or no pretreatment | no estimate extracted | NR | No studies |
Oestrogen compared to no pretreatment for ovarian stimulation protocols for women undergoing assisted reproductive techniques
Population: ovarian stimulation protocols for women undergoing ART
| Outcome | Effect | Evidence | Status / GRADE |
|---|---|---|---|
Live birth or ongoing pregnancy (Oestr + Ant vs Ant) Oestrogen vs no pretreatment | OR 0.79 [0.53, 1.17] | 2 studies · 502 participants | Moderate Downgraded: imprecision |
Live birth or ongoing pregnancy (Oestr + Ant vs Ag) Oestrogen vs no pretreatment | OR 0.88 [0.51, 1.5] | 2 studies · 242 participants | Very low Downgraded: risk of bias, imprecision |
Pregnancy loss (Oestr + Ant vs Ant) Oestrogen vs no pretreatment | OR 0.16 [0.02, 1.47] | 1 study · 49 participants | Very low Downgraded: risk of bias, imprecision |
Pregnancy loss (Oestr + Ant vs Ag) Oestrogen vs no pretreatment | OR 1.59 [0.62, 4.06] | 1 study · 220 participants | Very low Downgraded: risk of bias, imprecision |
Multiple pregnancy rate (Oestr + Ant vs Ant) Oestrogen vs no pretreatment | no estimate extracted | NR | No studies |
Multiple pregnancy rate (Oestr + Ant vs Ag) Oestrogen vs no pretreatment | OR 2.24 [0.09, 53.59] | 1 study · 22 participants | Very low Downgraded: risk of bias, imprecision |
OHSS rate (Oestr + Ant vs Ant) Oestrogen vs no pretreatment | no estimate extracted | NR | No studies |
OHSS rate (Oestr + Ant vs Ag) Oestrogen vs no pretreatment | OR 1.54 [0.25, 9.42] | 1 study · 220 participants | Very low Downgraded: risk of bias, imprecision |