Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

230 questions · 235 findings · 17 reviews

No studies found 71 · 30.2%GRADE not reported 17 · 7.2%Very low 70 · 29.8%Low 49 · 20.9%Moderate 20 · 8.5%High 8 · 3.4%

Summary of findings table ‐ 20 mL 1% lidocaine paracervical block vs normal saline paracervical block

Pain during procedure ‐ not measured · people requesting a surgical abortion at 13+6 weeks' gestation or less (Chin 2020 included people experiencing an early pregnancy loss)

The review found no eligible studies for this question.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Mucositis eradicated · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in mucositis eradicated compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Average pain scores (0-100 VAS) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in average pain scores (0-100 VAS) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) vs Salt and soda mouthwash

Time to heal mucositis (days) · People with cancer receiving chemotherapy or radiotherapy (or both) who have oral mucositis

'Magic' mouthwash (lidocaine, diphenhydramine, aluminium hydroxide) showed no clear difference in time to heal mucositis (days) compared with salt and soda mouthwash; GRADE not reported.

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs IM morphine

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of lidocaine intraperitoneal instillation plus… may leads to lower number of women requiring rescue medication compared with intramuscular morphine alone (low certainty).

1 finding from 1 review

Summary of findings table ‐ Two pumps of 10% cervical lidocaine spray and paracervical block vs two pumps of cervical normal saline spray and paracervical block

Pain with dilation ‐ not measured · people requesting a surgical abortion at seven weeks' gestation or less

The review found no eligible studies for this question.

1 finding from 1 review

Summary of findings table ‐ Two pumps of 10% cervical lidocaine spray and paracervical block vs two pumps of cervical normal saline spray and paracervical block

Pain with aspiration ‐ not measured · people requesting a surgical abortion at seven weeks' gestation or less

The review found no eligible studies for this question.

1 finding from 1 review

Combination of lidocaine intraperitoneal instillation plus intramuscular morphine vs placebo

Number of women requiring rescue medication · women undergoing PPTL under local anaesthesia

Combination of intraperitoneal lidocaine instillation and… may leads to lower number of women requiring rescue medication compared with placebo (low certainty).

1 finding from 1 review

2% mepivacaine, 1:20,000 levonordefrin vs 2% lidocaine, 1:100,000 epinephrine

Duration of anaesthesia (soft tissue, simulated) · Participants of any age and gender undergoing dental procedures, and volunteers who took part in simulated scenario studies in which…

It is very uncertain whether 2% mepivacaine, 1:20,000 levonordefrin changes duration of anaesthesia (soft tissue, simulated) compared with 2% lidocaine, 1:100,000 epinephrine (very low certainty).

1 finding from 1 review