Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

395 questions · 407 findings · 33 reviews

No studies found 113 · 27.8%GRADE not reported 39 · 9.6%Very low 91 · 22.4%Low 105 · 25.8%Moderate 50 · 12.3%High 9 · 2.2%

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in the total population randomised · critically ill patients

Intensive insulin therapy may leads to lower occurrence of CIP/CIM ‐ in total population randomised compared with conventional insulin therapy (low certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Occurrence of CIP/CIM ‐ in screened population · critically ill patients

Intensive insulin therapy probably leads to lower occurrence of CIP/CIM ‐ in screened population compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 30 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 30 days after ICU admission, in total population randomised compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Death ‐ at 180 days after ICU admission, in total population randomised · critically ill patients

Intensive insulin therapy showed no clear difference in death ‐ at 180 days after ICU admission, in total population… compared with conventional insulin therapy (moderate certainty).

1 finding from 1 review

Intensive insulin therapy vs conventional insulin therapy

Serious adverse events, ‐ in total population randomised ‐ hypoglycaemia · critically ill patients

Intensive insulin therapy leads to higher serious adverse events, ‐ in total population randomised ‐… compared with conventional insulin therapy (high certainty).

1 finding from 1 review

Intervention not reported

Potency/bioactivity parameters of human insulin · healthy physicians

The review found no eligible studies for this question.

1 finding from 1 review