Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

207 questions · 224 findings · 22 reviews · Vascular

No studies found 42 · 18.8%GRADE not reported 21 · 9.4%Very low 33 · 14.7%Low 81 · 36.2%Moderate 35 · 15.6%High 12 · 5.4%

Low molecular weight heparin and idraparinux vs usual care

Major bleeding · people > 18 years of age with a diagnosed deep vein thrombosis

The review found no eligible studies for this question.

2 findings from 1 review

Slow vs fast subcutaneous heparin injection

Bruise incidence ‐ 48 hours after injection · patients treated with subcutaneous heparin injections

Slow may leads to lower bruise incidence ‐ 48 hours after injection compared with fast subcutaneous heparin injection (low certainty).

2 findings from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC occlusion rate per 1000 catheter days Ability to infuse solution through CVC · infants and children with a long‐term CVC

It is very uncertain whether does normal saline flushing in long‐term central venous catheters… changes CVC occlusion rate per 1000 catheter days: ability to infuse… compared with heparin flushing (very low certainty).

1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC‐associated blood stream infection rate per 1000 catheter days Incidence of positive blood culture · infants and children with a long‐term CVC

Does normal saline flushing in long‐term central venous catheters… showed no clear difference in CVC‐associated blood stream infection rate per 1000 catheter days:… compared with heparin flushing (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

Major VTE events bilateral ascending venography1 · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors showed no clear difference in major VTE events bilateral ascending venography1 compared with low molecular weight heparins (low certainty).

1 finding from 1 review

Direct thrombin inhibitors vs low molecular weight heparin

All‐cause Mortality events · patients with prevention of venous thromboembolism following total hip or knee replacement

Direct thrombin inhibitors probably leads to higher all‐cause Mortality events compared with low molecular weight heparins (moderate certainty).

1 finding from 1 review