What do systematic reviews say?

Very high protein vs high protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 48 participants
  Low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 18 participants
  Very low

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

High protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 46 participants
  Low

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Very high protein vs low protein intake (restricted to studies meeting all a priori inclusion criteria)

The review found no eligible studies for this question.

• Higher versus lower protein intake in formula‐fed low birth weight infants 2020 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Hydrolysed vs non‐hydrolysed formula

Hydrolysed showed no clear difference in feed intolerance compared with non‐hydrolysed formula (low certainty).

• Protein hydrolysate versus standard formula for preterm infants 2019 · Cochrane Headline outcomes only
  RR 2.71 [0.29, 25]
  3 studies · 161 participants
  Low

Hydrolysed vs non‐hydrolysed formula

Hydrolysed showed no clear difference in necrotising enterocolitis compared with non‐hydrolysed formula (low certainty).

• Protein hydrolysate versus standard formula for preterm infants 2019 · Cochrane Headline outcomes only
  RR 1.1 [0.36, 3.34]
  5 studies · 385 participants
  Low

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

The review found no eligible studies for this question.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
  No studies reported this outcome
  0 studies
  No studies found

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

The review found no eligible studies for this question.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
  No studies reported this outcome
  0 studies
  No studies found

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

The review found no eligible studies for this question.

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
  No studies reported this outcome
  0 studies
  No studies found

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes
  Healing: 2 studies (Faizel 2015; Supe 2018) used different healing outcomes and could not be combined; Alvogyl appeared to heal faster than zinc oxide eugenol. Supe 2018: delayed (non-healed after 10 days) 2/25 Alvogyl…
  2 studies
  GRADE not reported

Zinc oxide and eugenol (ZOE) vs Alvogyl (old formulation)

It is very uncertain whether zinc oxide eugenol changes pain (VAS 0-10) compared with alvogyl (old formulation) (very low certainty).

• Local interventions for the management of alveolar osteitis (dry socket) 2022 · Cochrane All outcomes

  Day 7
  MD 1.40 [1.04, 1.75]
  2 studies · 80 participants
  Very low

High vs standard volume of fortified human milk or preterm formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 271 participants
  Moderate

High vs standard volume of unfortified human milk or term formula

It is very uncertain whether high changes necrotising enterocolitis compared with standard volume of unfortified human milk or term formula (very low certainty).

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  RR 1.03 [0.07, 15.78]
  1 study · 61 participants
  Very low

High vs standard volume of fortified human milk or preterm formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 271 participants
  Low

High vs standard volume of fortified human milk or preterm formula

• High versus standard volume enteral feeds to promote growth in preterm or low birth weight infants 2021 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 271 participants
  Low