Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

179 questions · 185 findings · 25 reviews · Neonatal

No studies found 20 · 10.8%GRADE not reported 14 · 7.6%Very low 45 · 24.3%Low 59 · 31.9%Moderate 37 · 20%High 10 · 5.4%

Regional (spinal, epidural, caudal) vs general anaesthesia

Any oxygen desaturation occurring 12‐24 hours following completion of the operation · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in any oxygen desaturation occurring 12‐24 hours following completion… compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Use of post‐operative respiratory support · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in use of post‐operative respiratory support compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Post‐operative apnoea with preoperative sedatives excluded · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) probably leads to lower post‐operative apnoea with preoperative sedatives excluded compared with general anaesthesia (moderate certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic agent failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) may leads to higher anaesthetic agent failure compared with general anaesthesia (low certainty).

1 finding from 1 review

Regional (spinal, epidural, caudal) vs general anaesthesia

Anaesthetic placement failure · Preterm infants requiring surgery for inguinal hernia in early infancy

Regional (spinal, epidural, caudal) showed no clear difference in anaesthetic placement failure compared with general anaesthesia (low certainty).

1 finding from 1 review

NIPPV vs NCPAP

Need for endotracheal tube ventilation · )

Nasal intermittent positive pressure ventilation (NIPPV) probably leads to lower need for endotracheal tube ventilation compared with nasal continuous positive airway pressure (NCPAP) (by population) (moderate certainty).

1 finding from 1 review

NIPPV vs NCPAP

Severe (grade 3 or greater) intraventricular hemorrhage (IVH) on cranial ultrasound ‐ not reported · )

Nasal intermittent positive pressure ventilation (NIPPV) showed no clear difference in severe intraventricular hemorrhage (grade III/IV) compared with nasal continuous positive airway pressure (NCPAP) (by population) (low certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Combined outcome of death and bronchopulmonary dysplasia defined as death at any time and oxygen dependency at 36 weeks' postmenstrual age · preterm infants

Prophylactic CPAP probably leads to lower combined outcome of death and bronchopulmonary dysplasia defined as… compared with mechanical ventilation (moderate certainty).

1 finding from 1 review

Prophylactic CPAP vs mechanical ventilation

Failed treatment defined as the need for mechanical ventilation · preterm infants

Prophylactic CPAP probably leads to lower failed treatment defined as the need for mechanical ventilation compared with mechanical ventilation (moderate certainty).

1 finding from 1 review