Time from drug administration to stopping of seizures · Children with acute tonic‐clonic seizures
1 finding from 1 review
Incidence of respiratory depression · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in incidence of respiratory depression compared with intravenous diazepam (moderate certainty).
1 finding from 1 review
Additional drugs required to stop the seizure: additional dose of the trial drug required · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in additional drugs required to stop the seizure: additional dose of… compared with intravenous diazepam (moderate certainty).
1 finding from 1 review
Seizure recurrence within 24 hours · Children with acute tonic‐clonic seizures
Summary of findings ‐ Intravenous midazolam showed no clear difference in seizure recurrence within 24 hours compared with intravenous diazepam (moderate certainty).
1 finding from 1 review
Incidence of admissions to the ICU · Children with acute tonic‐clonic seizures
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Awareness Postoperative interview · patients with prevention of recall of events during surgery
It is very uncertain whether thiopentone and ketamine changes awareness Postoperative interview compared with benzodiazepines (diazepam, midazolam, lorazepam) (very low certainty).
1 finding from 1 review
Adverse effects of intraoperative wakefulness and/or postoperative awareness (i.e. post‐traumatic stress syndrome, myocardial infarction, cardiac arrest, etc.) · patients with prevention of recall of events during surgery
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Level of sedation on a sedation assessment scale · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
1 finding from 1 review
Anxiety · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
Intravenous midazolam showed no clear difference in numeric rating of anxiety or rated as anxious compared with diazepam (low certainty).
1 finding from 1 review
Incomplete procedure · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
1 finding from 1 review
Anterograde amnesia (defined by number of participants who recalled the procedure) · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
Intravenous midazolam may leads to lower anterograde amnesia (defined by number of participants who recalled… compared with diazepam (low certainty).
1 finding from 1 review
Disinhibition or excitation · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Discomfort/pain · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
Intravenous midazolam showed no clear difference in discomfort/pain compared with diazepam (low certainty).
1 finding from 1 review
Allergic or anaphylactoid reaction · adults and children requiring sedation before gastrointestinal endoscopy and bronchoscopy
The review found no eligible studies for this question.
1 finding from 1 review
no estimate extracted
Studies not reported
No studies found
Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV probably leads to lower non‐cessation of seizures compared with diazepam IV (moderate certainty).
1 finding from 1 review
Requirement for ventilatory support · patients with status epilepticus
Lorazepam IV showed no clear difference in requirement for ventilatory support compared with diazepam IV (low certainty).
1 finding from 1 review
Adverse effects · patients with status epilepticus
1 finding from 1 review
Continuation of status requiring a different drug or general anaesthesia · patients with status epilepticus
Lorazepam IV probably leads to lower continuation of status requiring a different drug or general… compared with diazepam IV (moderate certainty).
1 finding from 1 review
Death · patients with status epilepticus
1 finding from 1 review
Non‐cessation of seizures · patients with status epilepticus
Lorazepam IV showed no clear difference in non‐cessation of seizures compared with diazepam plus phenytoin IV (low certainty).
1 finding from 1 review