Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,938 questions · 1,994 findings · 246 reviews · Headline outcomes only

No studies found 490 · 24.6%GRADE not reported 71 · 3.6%Very low 669 · 33.6%Low 446 · 22.4%Moderate 264 · 13.2%High 54 · 2.7%

Microcatheter‐assisted trabeculotomy vs conventional trabeculotomy

Hyphema · children at or before five years of age with primary congenital glaucoma

Microcatheter‐assisted trabeculotomy probably leads to higher adverse outcomes— hyphema Up to 1 year after surgery compared with conventional trabeculotomy (moderate certainty).

1 finding from 1 review

Hydrosurgery vs conventional 'open' surgical debridement

Post-operative infection · acute partial‐thickness burns prior to skin grafting

It is very uncertain whether hydrosurgery changes postoperative infection (number of participants with post‐operative… compared with conventional debridement (very low certainty).

1 finding from 1 review

External uterine compression (all methods) plus normal care vs normal care

Mortality due to bleeding ‐ not reported · women diagnosed with primary PPH following vaginal birth. PPH was defined as quote: "blood loss > 500mL after delivery" p 601

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mortality due to bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes mortality due to bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Hysterectomy to control bleeding · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes hysterectomy to control bleeding compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Serious maternal morbidity (renal or respiratory failure, cardiac arrest or multiple organ failure) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Number of women with total blood loss 1000 mL or more after randomisation · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

It is very uncertain whether intrauterine balloon tamponade plus normal care (misoprostol) changes number of women with total blood loss 1000 mL or more after… compared with normal care (misoprostol) (very low certainty).

1 finding from 1 review

Intrauterine balloon tamponade plus normal care (misoprostol) vs normal care (misoprostol)

Mean blood loss (mL) (trialist defined) · women diagnosed with primary PPH following vaginal birth. Women were suspected to have PPH due to clinical atony and who were quote:…

The review found no eligible studies for this question.

1 finding from 1 review