Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,534 questions · 5,247 findings · 456 reviews

No studies found 1,142 · 21.8%GRADE not reported 1,503 · 28.6%Very low 1,040 · 19.8%Low 869 · 16.6%Moderate 554 · 10.6%High 139 · 2.6%

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Ventilation tubes vs no treatment

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether ventilation tubes changes adverse event: persistent perforation Randomised by ear, assumed CC… compared with no treatment (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Hearing ‐ return to normal *Ventilation tubes versus laser myringotomy (6 to 12 months ‐ medium‐term) Adjusted for non‐independence of within‐individual measurements Assumed ICC of 0.5 № of participants: 132 (2 RCTs) · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes hearing ‐ return to normal hearing Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Presence/persistence of OME · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes presence/persistence of OME Randomised by child compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Early ventilation tubes vs watchful waiting

Adverse event: persistent perforation · children aged 6 months to 12 years with otitis media with effusion (OME)

It is very uncertain whether early ventilation tubes changes adverse event: persistent perforation compared with watchful waiting (treatment later if required) (very low certainty).

1 finding from 1 review

Intervention not reported

Nicotine tapering · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in nicotine tapering (low certainty).

1 finding from 1 review

Intervention not reported

Nicotine patch · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in nicotine patch (low certainty).

1 finding from 1 review

Intervention not reported

Fast‐acting NRT (nicotine other) · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in fast‐acting NRT (nicotine other) (low certainty).

1 finding from 1 review

Intervention not reported

Bupropion · adults (aged ≥ 18 years) who smoked cigarettes Components: components of pharmacological and e‐cigarette (EC) interventions for smoking…

The intervention showed no clear difference in bupropion (moderate certainty).

1 finding from 1 review