DMFT/DMFS index (dental caries experience) · Children aged 6 years and older (healthy except for dental caries)
In children aged 6 years and older, OHPPs showed no significant effect on DMFT/S (OR 0.29, 95% CI 0.08 to 1.01; ungraded).
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
1 finding from 1 review
Additional SoF Table 1. Adverse effects: with placebo gel 0.60%; with fluoride gel 0.00% (0 to 0); difference 0.60% fewer (0.60 fewer to 0.60 fewer); relative effect not estimable; 312 participants (1 RCT); certainty…
1 study · 312 participants
Very low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
1000 to 1250 ppm F toothpaste leads to lower caries increment, surface index D(M)FS compared with non-fluoride (0 ppm F) placebo toothpaste (high certainty).
1 finding from 1 review
SMD -0.28 [-0.32, -0.25]
55 studies
High
Number of participants with new demineralised lesions (DLs) · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
Professionally-applied 12,300 ppm F APF foam, every 2 months may leads to lower number of participants with new demineralised lesions (DLs) compared with 0 ppm F placebo foam (low certainty).
1 finding from 1 review
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
2400 to 2800 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 1450 to 1500 ppm F toothpaste (moderate certainty).
1 finding from 1 review
SMD -0.05 [-0.14, 0.05]
2 studies
Moderate
Proportion developing new caries · Young children with primary (deciduous) dentition (aged 1 to 6 years at study start)
1450 ppm F toothpaste showed no clear difference in proportion developing new caries compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
Plaque index (PI) / oral hygiene · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
It is very uncertain whether 1400/250 ppm F (amine F/SnF2) toothpaste + mouthrinse, daily changes visible plaque index (mean change from baseline) compared with 1400/250 ppm F (NaF) toothpaste + mouthrinse, daily (very low certainty).
1 finding from 1 review
Caries increment, tooth index D(M)FT · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
250 ppm F toothpaste showed no clear difference in caries increment, tooth index D(M)FT compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
SMD -0.11 [-0.27, 0.05]
1 study
Low
Incremental cost‐effectiveness · Children with dental caries
OHPPs were associated with a lower program cost per DMFT/S in about 97 of 100 programs (OR 0.03, 95% CI 0.01 to 0.11; ungraded, very high heterogeneity I2=99%).
1 finding from 1 review
OR 0.03 [0.01, 0.11]
8 studies
GRADE not reported
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
The review found no eligible studies for this question.
1 finding from 1 review
Adverse effects · Orthodontic patients of any age with fixed braces (new DLs assessed at debond)
1 finding from 1 review
SoF 1. Adverse effects: no evidence that the intervention had adverse effects; only 1 participant with an adverse event and unclear if directly related to the intervention. 148 participants (1 RCT, Sonesson 2019);…
1 study · 148 participants
Low
Caries increment, surface index D(M)FS · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
440 to 550 ppm F toothpaste showed no clear difference in caries increment, surface index D(M)FS compared with 250 ppm F toothpaste (low certainty).
1 finding from 1 review
SMD 0.03 [-0.17, 0.23]
1 study
Low
Proportion developing new caries · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)
250 ppm F toothpaste showed no clear difference in proportion developing new caries compared with non-fluoride (0 ppm F) placebo toothpaste (low certainty).
1 finding from 1 review
DMFT/DMFS index (dental caries experience) · Children younger than 6 years (healthy except for dental caries)
In children younger than 6 years, OHPPs were associated with lower odds of DMFT/S (OR 0.14, 95% CI 0.05 to 0.39; ungraded).
1 finding from 1 review
Adverse effects · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
New types of fissure sealant (e.g. ormocer-based) vs No sealant (control)
Outcome not reported · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review
Caries on occlusal surfaces of permanent molars (12 months) · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant (2nd/3rd/4th generation) led to lower caries on occlusal surfaces of permanent molars (36 months) compared with no sealant (control/no treatment); GRADE not reported.
3 findings from 1 review
OR 0.17 [0.11, 0.27]
7 studies
GRADE not reported
OR 0.21 [0.16, 0.28]
4 studies
GRADE not reported
OR 0.17 [0.10, 0.30]
7 studies
GRADE not reported
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
1 finding from 1 review
Inconclusive results: two studies slightly favoured glass ionomers (Liu 2014b OR 0.46 (0.23-0.91); Tagliaferro 2011) evaluating 426 children; one study (Songpaisan 1995) found no difference (MD DFS -0.18 (-0.39 to…
3 studies · 830 participants
Very low
Dentine caries in permanent molars (24 months) · Children and adolescents (general population, aged under 20 years)
Resin-based fissure sealant (2nd/3rd/4th generation) probably leads to lower dentine caries in permanent molars (24 months) compared with no sealant (control/no treatment) (moderate certainty).
1 finding from 1 review
Adverse effects · Children and adolescents (general population, aged under 20 years)
The review found no eligible studies for this question.
1 finding from 1 review