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Evidence found and GRADE certainty

4,808 questions · 8,953 findings · 827 reviews · Headline outcomes only

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No studies found 1,891 · 21.1%GRADE not reported 380 · 4.2%Very low 2,100 · 23.5%Low 2,449 · 27.4%Moderate 1,684 · 18.8%High 449 · 5%

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Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + GLP1‐A
2 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + DPP4‐I

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + DPP4‐I compared with metformin plus another antidiabetic drug (very low certainty).

3 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + thiazolidinedione

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + thiazolidinedione compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + nateglinide
4 findings from 1 review
Show 1 more finding

Metformin‐sulphonylurea (second‐ or third‐generation) combination therapy vs metformin plus another antidiabetic drug

M + SGLT2‐I

It is very uncertain whether metformin‐sulphonylurea (second‐ or third‐generation) combination… changes M + SGLT2‐I compared with metformin plus another antidiabetic drug (very low certainty).

2 findings from 1 review

Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control

Global state ‐ number of participants with relapse/exacerbations of psychosis (combined time points) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Summary of findings table ‐ Cognitive behavioural therapy plus… showed no clear difference in global state ‐ number of participants with relapse/exacerbations of… compared with control (low certainty).

1 finding from 1 review

Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control

Leaving the study early ‐ for any reason ‐ overall acceptability (combined time points) · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

Summary of findings table ‐ Cognitive behavioural therapy plus… showed no clear difference in leaving the study early ‐ for any reason ‐ overall acceptability… compared with control (moderate certainty).

1 finding from 1 review

Summary of findings table ‐ Cognitive behavioural therapy plus standard care vs control

Risk for at least one adverse event per patient · recent‐onset psychosis (less than three years since the start of psychotic symptoms and either first or second psychotic episode)

It is very uncertain whether summary of findings table ‐ Cognitive behavioural therapy plus… changes adverse events ‐ participants with at least one adverse event ‐ < 12… compared with control (very low certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Number with frequent relapses by 12 to 24 months stratified by risk of selection bias: Low risk of selection bias · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in subgroup analysis by risk of bias for number with frequent relapses:… compared with three months (high certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Subgroup analysis by risk of bias for number with frequent relapses: Unclear or high risk of selection bias · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… probably leads to lower subgroup analysis by risk of bias for number with frequent relapses:… compared with three months (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Adverse events: hypertension · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in adverse events: hypertension compared with three months (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Adverse events: eye complications · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in adverse events: eye complications compared with three months (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Adverse events: Cushingoid appearance · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in adverse events: Cushingoid appearance compared with three months (moderate certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Adverse events: psychological disorders · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in adverse events: psychological disorders compared with three months (low certainty).

1 finding from 1 review

Steroid therapy in first episode of nephrotic syndrome: five to seven months vs three months

Frequent relapses · children with nephrotic syndrome

Steroid therapy in first episode of nephrotic syndrome: five to… showed no clear difference in number with frequent relapses by 12 to 24 months compared with three months (moderate certainty).

1 finding from 1 review