What do systematic reviews say?

Removable appliance with palatal crib associated with high-pull chincup vs no treatment

Removable appliance with palatal crib associated with high-pull… led to lower failure to correct the anterior open bite (open bite not closed) compared with no treatment; GRADE not reported.

• Orthodontic and orthopaedic treatment for anterior open bite in children 2014 · Cochrane All outcomes

  End of treatment (12 months)
  RR 0.23 [0.11, 0.48]
  1 study · 60 participants
  GRADE not reported

Intervention not reported

The review found no eligible studies for this question.

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

The review found no eligible studies for this question.

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  19 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  20 participants
  Very low

Intervention not reported

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  20 participants
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Cervico‐thoracic or lumbar sympathectomy for neuropathic pain and complex regional pain syndrome 2013 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  16 weeks
  Two patients in each group reported unwanted effects.
  1 study
  GRADE not reported

Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)

• Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes

  16 weeks
  A trial at high risk of bias (Zissis 1983) compared two different dose regimens of levamisole (treatment 2 days per week for 16 weeks; a third group received placebo). There was inconsistency in the presentation of the…
  1 study
  GRADE not reported

Higher‐dose vs lower dose

It is very uncertain whether higher dose changes deaths compared with lower dose (very low certainty).

• Oximes for acute organophosphate pesticide poisoning 2011 · Cochrane Headline outcomes only
  OR 0.38 [0.1, 1.47]
  4 studies · 479 participants
  Very low

Higher‐dose vs lower dose

It is very uncertain whether higher dose changes intermediate syndrome compared with lower dose (very low certainty).

• Oximes for acute organophosphate pesticide poisoning 2011 · Cochrane Headline outcomes only
  OR 0.94 [0.24, 3.62]
  3 studies · 283 participants
  Very low

Higher‐dose vs lower dose

It is very uncertain whether higher dose changes ventilated compared with lower dose (very low certainty).

• Oximes for acute organophosphate pesticide poisoning 2011 · Cochrane Headline outcomes only
  OR 0.72 [0.08, 6.35]
  2 studies · 272 participants
  Very low

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  11 studies · 765 participants
  High

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  22 studies · 3117 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (moderate certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  35 studies · 4869 participants
  Moderate

Intervention not reported

The intervention showed no clear difference in mg/day LDL cholesterol (high certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 881 participants
  High

Intervention not reported

The review found no eligible studies for this question.

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Intervention not reported

It is very uncertain whether the intervention changes WDAEs (very low certainty).

• Pravastatin for lowering lipids 2023 · Cochrane Headline outcomes only
  RR 0.81 [0.63, 1.03]
  33 studies · 6187 participants
  Very low

High‐protein formula vs standard‐protein formula

• Higher versus lower protein intake in formula‐fed term infants 2023 · Cochrane Headline outcomes only
  no estimate extracted
  7 studies · 1629 participants
  Very low