Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

3,454 questions · 3,562 findings · 816 reviews · Headline outcomes only

No studies found 538 · 15.1%GRADE not reported 239 · 6.7%Very low 933 · 26.2%Low 1,041 · 29.2%Moderate 612 · 17.2%High 199 · 5.6%

Intervention not reported

IPC –not daily drainage (2 RCTs, 160 participants) VAS scores at 42 days and 180 days · adults with malignant pleural effusion Interventions: talc poudrage, bleomycin, IPC – not daily drainage, doxycycline, placebo Comparator…
1 finding from 1 review

Oral magnesium vs placebo/no treatment

Intensity of pain during treatment: mean total scale points The degree of pain was noted in the form, on a scale from 0 to 4 measured over 4 days and nights (0 = no pain, 1 = light pain, 2 = medium pain, 3=strong pain, 4=extreme pain) · treating leg cramps in pregnancy
1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC occlusion rate per 1000 catheter days Ability to infuse solution through CVC · infants and children with a long‐term CVC

It is very uncertain whether does normal saline flushing in long‐term central venous catheters… changes CVC occlusion rate per 1000 catheter days: ability to infuse… compared with heparin flushing (very low certainty).

1 finding from 1 review

Does normal saline flushing in long‐term central venous catheters (CVC) prevent occlusion vs heparin flushing

CVC‐associated blood stream infection rate per 1000 catheter days Incidence of positive blood culture · infants and children with a long‐term CVC

Does normal saline flushing in long‐term central venous catheters… showed no clear difference in CVC‐associated blood stream infection rate per 1000 catheter days:… compared with heparin flushing (low certainty).

1 finding from 1 review

Intervention not reported

Transepidermal water loss (TEWL) Measured using temperature‐adjusted g/m²/h with the Tewameter TM 300 (Courage + Khazaka, Cologne, Germany) Hahnel 2017: measured at 56 ± 4 days Shishido 2017: measured 15 minutes after wiping the skin with a dry to... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Stratum corneum hydration (SCH) (at baseline and day 56 ± 4) Hahnel 2017: measured at 56 ± 4 days in mid‐volar arm and lower leg in arbitrary units from 0 (no water) to 120 (on water) using the Corneometer CM 825 Gillis 2016: measured at 12 weeks ... · people 60 years of age and older
1 finding from 1 review

Intervention not reported

Clinical score of dryness Hahnel 2017: measured at day 56 ± 4 using the Overall Dry Skin Score Boccanfuso 1978: measured after 10 applications using a non‐validated General Foot Condition Questionnaire including a Dryness Scale (1 = oily; 2 = norm... · people 60 years of age and older
1 finding from 1 review

Laxative plus bulking agent vs laxative alone

Adverse effects on women: faecal incontinence during first 10 postpartum days · postpartum women who underwent surgical repair of third degree perineal tears

It is very uncertain whether laxative plus bulking agent changes adverse effects on women: faecal incontinence during first 10… compared with laxative alone (very low certainty).

1 finding from 1 review

Laxative vs placebo

Time to first BM (№ women with 1st BM on day 1 after delivery) · women in the postpartum period

It is very uncertain whether laxative changes time to first BM (№ women with 1st BM on day 1 after delivery) compared with placebo (very low certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Blood transfusion · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron probably leads to lower transfusion (measured in participants during or up to 5 days after… compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Number of RBC units transfused per participant (intraoperative to 5 days postoperative) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia
1 finding from 1 review

rHuEPO with iron vs control treatment with or without iron

Mortality (within 30 days after surgery) · adult participants, irrespective of gender and type of non‐cardiac surgery, with mild or severe preoperative anaemia

rHuEPO with iron showed no clear difference in mortality (within 30 days after surgery) compared with control treatment with or without iron (moderate certainty).

1 finding from 1 review