Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

4,776 questions · 7,311 findings · 959 reviews · Headline outcomes only

No studies found 1,498 · 20.5%GRADE not reported 303 · 4.1%Very low 1,839 · 25.2%Low 1,991 · 27.2%Moderate 1,277 · 17.5%High 403 · 5.5%

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Serotonin and noradrenaline reuptake inhibitors (SNRI) vs placebo

Self‐reported health‐related quality of life (0‐100 scale) Higher scores indicate higher burden of disease (lower quality of life) · patients with fibromyalgia

Serotonin noradrenaline reuptake inhibitors showed no clear difference in self‐reported health‐related quality of life (0‐100 scale) Higher… compared with placebo (low certainty).

1 finding from 1 review

FIBRINOGEN: Therapeutic trials: intervention vs inactive control

All‐cause mortality Up to 28 days following admission · the prevention and treatment of bleeding in patients without haemophilia

FIBRINOGEN: Therapeutic trials: intervention showed no clear difference in all‐cause mortality Up to 28 days following admission compared with inactive Control (moderate certainty).

1 finding from 1 review

Laparoscopic retroperitoneal adrenalectomy vs laparoscopic transperitoneal adrenalectomy

Early morbidity (any complication during the first 30 to 60 days following surgery)

It is very uncertain whether laparoscopic retroperitoneal adrenalectomy changes early morbidity (any complication during the first 30 to 60 days… compared with laparoscopic transperitoneal adrenalectomy (very low certainty).

1 finding from 1 review

Laparoscopic retroperitoneal adrenalectomy vs laparoscopic transperitoneal adrenalectomy

Late morbidity (any complication following surgery at latest available

It is very uncertain whether laparoscopic retroperitoneal adrenalectomy changes late morbidity (any complication following surgery at latest available compared with laparoscopic transperitoneal adrenalectomy (very low certainty).

1 finding from 1 review

De‐escalation vs usual care

Physically aggressive behaviour (validated scale) Measured by: Cohen‐Mansfield Agitation Inventory ‐ Physically Aggressive Behaviour Scale (9 items rated on 7‐point scale, ranging from 1 (never occurs) to 7 (occurs several times an hour); lower sc... · people with dementia
1 finding from 1 review

De‐escalation vs usual care

Verbally aggressive behaviour (validated scale) Measured by: Cohen‐Mansfield Agitation Inventory ‐ Verbally Aggressive Behaviour Scale (3 items rated on 7‐point scale, ranging from 1 (never occurs) to 7 (occurs several times an hour); lower score ... · people with dementia
1 finding from 1 review