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Evidence found and GRADE certainty

2,066 questions · 3,346 findings · 178 reviews · Dental caries

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No studies found 48 · 1.4%GRADE not reported 2,789 · 83.4%Very low 208 · 6.2%Low 129 · 3.9%Moderate 136 · 4.1%High 36 · 1.1%

GG genotype of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs3796704 and dental caries susceptibility (GG vs AA model: OR 1.86, 95% CI 0.96-3.62); certainty not graded.

6 findings from 1 review
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No additional acid etching (self-etch adhesive alone) after Er,Cr:YSGG preparation vs Prior acid etching before self-etch adhesive after Er,Cr:YSGG preparation

Incidence of microleakage · Er,Cr:YSGG laser-prepared cavities restored with self-etch adhesive systems (in vitro)

At the dentin margin, prior acid etching with self-etch adhesives significantly reduced microleakage (RR 2.44, 95% CI 1.38-4.34; ungraded).

3 findings from 1 review

AG + GG genotype (G-allele carriers) of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of LTF rs1126478 and dental caries susceptibility (AG + GG vs AA model: OR 0.99, 95% CI 0.81-1.23) in the Age group: Children subgroup; certainty not graded.

5 findings from 1 review
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GG genotype of ENAM rs1264848 vs AA genotype of ENAM rs1264848

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of ENAM rs1264848 and dental caries susceptibility (GG vs AA model: OR 0.58, 95% CI 0.19-1.82) in the Age group: Children subgroup; certainty not graded.

6 findings from 1 review
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rs1126478 genotype distribution vs Caries-free control genotype distribution

Dental caries (by severity) · Human subjects stratified by dental caries severity and caries-free controls

rs1126478 was inversely associated with low-level dental caries in a single study (OR 0.65, 95% CI 0.47 to 0.90; ungraded).

6 findings from 1 review
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Low birth weight (<2500 g) vs Normal birth weight (2500 g or more)

Early childhood caries (ECC) · Children aged 6 years or younger (preschool children)

Adjusted analyses also showed no association between low birth weight and early childhood caries (adjusted OR 1.05, 95% CI 0.71 to 1.57); certainty not graded.

3 findings from 1 review

Traditional bur cavity preparation vs Er,Cr:YSGG laser cavity preparation

Incidence of microleakage · Human teeth requiring cavity preparation and restoration (in vitro)

At the dentin margin, microleakage did not differ significantly between bur and Er,Cr:YSGG laser preparation (RR 1.26, 95% CI 0.67-2.38; ungraded).

4 findings from 1 review
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Tooth-coloured direct restorative materials (composite, compomer, giomer, RMGIC, HVGIC, open-sandwich) vs No comparator

Anatomic form success rate · Children with primary molars requiring proximal (Class II) restorations

The pooled 24-month anatomic form success rate was 0.901 (95% CI 0.845-0.938; ungraded).

2 findings from 1 review

T allele of ENAM rs3796703 vs C allele of ENAM rs3796703

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between T allele vs C allele of ENAM rs3796703 and dental caries susceptibility (T vs C model: OR 0.92, 95% CI 0.24-3.58); certainty not graded.

3 findings from 1 review

TT genotype of AMELX rs17878486 vs CC + CT genotype of AMELX rs17878486

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between TT genotype vs CC + CT genotype of AMELX rs17878486 and dental caries susceptibility (TT vs CC + CT model: OR 6.17, 95% CI 0.41-92.05) in the Ethnicity: Caucasian subgroup; certainty not graded.

8 findings from 1 review
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CT genotype of AMELX rs6639060 vs CC genotype of AMELX rs6639060

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between CT genotype vs CC genotype of AMELX rs6639060 and dental caries susceptibility (CT vs CC model: OR 1.27, 95% CI 0.49-3.30) in the Age group: Adults subgroup; certainty not graded.

3 findings from 1 review

Fluoride varnish vs Fissure sealant (resin-based or glass ionomer)

Caries incidence of first permanent molars (FPMs) · Generally healthy children aged 6 to 9 years with at least one fully erupted first permanent molar with deep fissures or early enamel…

After excluding the high-risk-of-bias study (Bravo 1996), fluoride varnish and fissure sealant did not differ in caries incidence of FPMs and heterogeneity fell to 0% (RR 1.05, 95% CI 0.91 to 1.22; 5 RCTs; ungraded).

3 findings from 1 review

AG + GG genotype (G-allele carriers) of ENAM rs3796704 vs AA genotype of ENAM rs3796704

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between AG + GG genotype (G-allele carriers) vs AA genotype of ENAM rs3796704 and dental caries susceptibility (AG + GG vs AA model: OR 0.24, 95% CI 0.03-2.17) in the Ethnicity: Mixed subgroup; certainty not graded.

6 findings from 1 review
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GG genotype of LTF rs1126478 vs AA genotype of LTF rs1126478

Dental caries susceptibility · Individuals assessed for dental caries (cases with caries/high caries vs. caries-free or low/very-low-caries controls)

No significant association between GG genotype vs AA genotype of LTF rs1126478 and dental caries susceptibility (GG vs AA model: OR 0.97, 95% CI 0.73-1.29) in the Ethnicity: Asian subgroup; certainty not graded.

5 findings from 1 review
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